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Functional Assay of Neural Activity with Cell-Based Neural Culture Models and Microelectrode Array Technology for Proconvulsant Risk Assessment in the Neutox Pilot Study
EP30058
Poster Title: Functional Assay of Neural Activity with Cell-Based Neural Culture Models and Microelectrode Array Technology for Proconvulsant Risk Assessment in the Neutox Pilot Study
Submitted on 23 Apr 2019
Author(s): Millard, D.C.; Hayes, H.B.; Nicolini, A.M.; Arrowood, C.A.; Clements, M;
Affiliations: Axion BioSystems, Lonza
This poster was presented at SOT 2019
Poster Views: 282
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Poster Information
Abstract: The detection of seizurogenic activity is critical for assessments in neurotoxicology and safety pharmacology, highlighted by the efforts of the international HESI NeuTox consortium. This session will demonstrate how rodent cortical neurons and microelectrode technology can evaluate neuro-active and seizurogenic effects with example data from the HESI NeuTox pilot study.Summary: The HESI NeuTox pilot study produced in vitro MEA data from rodent primary and hiPSC-derived neuronal cultures evaluated against 12 compounds by stakeholders invested in benchmarking a functional cell-based assay for seizure-liability assessment. Report abuse »
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