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Gene Mining Spinal and Dental Phenotypes of the Collaborative Cross
EP29021
Gene Mining Spinal and Dental Phenotypes of the Collaborative Cross
Submitted on 10 Oct 2018

Samuel Bennett, Eason Guo, Curtise Ng, Grant Morahan, Jennifer Tickner, Jiake Xu
The University of Western Australia, Curtin University of Technology
This poster was presented at The Australian and New Zealand Bone Mineral Society 2018 Conference
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Poster Abstract
The Collaborative Cross (CC) is a systems genetics resource [1]. The Gene Mine (the WA component of the CC) is a recombinant inbred panel of >1000 mice from over 80 strains, generated and housed at the Animal Resources Centre, Perth [2]. A primary aim of the CC is to provide a stable, reproducible genetic reference platform for quantitative and qualitative analysis of gene-variants, epistatic mechanisms, and environmental factors resulting in disease [3]. We are screening the Gene Mine CC population for spinal and dentofacial deformities. Our aim is to answer the question: “How are these deformities genetically connected?”


1. Threadgill DW and Churchill GA. Genetics, 190: 291-94, 2012.
2. Morahan G, Balmer L, and Monley D. Mamm Genome, 19: 390-393, 2008.
3. The Complex Trait Consortium. Nature Genetics, 36: 1133-1137, 2004.
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