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Gene Mining the Spinal and Dental Phenotypes of the Collaborative Cross
EP29253
Poster Title: Gene Mining the Spinal and Dental Phenotypes of the Collaborative Cross
Submitted on 10 Oct 2018
Author(s): Samuel Bennett, Eason Guo, Curtise Ng, Grant Morahan, Jennifer Tickner, Jiake Xu
Affiliations: The University of Western Australia, Curtin University of Technology
This poster was presented at Australian and New Zealand Orthodontic Research Society 2018
Poster Views: 698
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Poster Information
Abstract: The Gene Mine is the WA component of The Collaborative Cross (CC): a systems genetics resource, consisting of a purpose-built recombinant inbred panel of >1000 mice from over 80 strains, that have been generated and housed at the Animal Resources Centre, Perth [1, 2].

A central aim of The Gene Mine is to provide a stable, reproducible genetic reference platform for quantitative and qualitative analysis of gene-variants, epistatic mechanisms, and environmental factors resulting in disease [3].

We are screening the Gene Mine CC population for spinal and dentofacial deformities.
Summary: We are investigating the spinal and dental disease phenotypes of the Collaborative Cross mice population. References:
1. Threadgill DW and Churchill GA. Genetics, 190: 291-94, 2012.
2. Morahan G, Balmer L, and Monley D. Mamm Genome, 19: 390-93, 2008.
3. The Complex Trait Consortium. Nature Genetics, 36: 1133-1137, 2004.
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