Abstract: Histone modifications change chromatin structures or recruit histone modifiers, causing change in gene expressions. The PTMs are involved in diverse biological processes including transcriptional regulation, chromosome packaging, and DNA damage/repair. Thus, profiling of various histone modifications would provide important information to better understand the epigenetic mechanisms underlying cellular processes and the development of drugs targeting histone and their modifications.Summary: Histone can be covalently post-translational modified. At least nine different types of post-translational modifications (PTMs) to histones have been identified, such as methylation, acetylation, phosphorylation, ubiquitylation, and sumoylation. References: https://www.cd-genomics.com/wp-content/themes/v1/pdf/main/Genome-Wide-Profiling-of-Histone-Modifications-with-ChIP-Seq.pdf
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