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Hematopoietic Stem Cell Transplantation: Are We There Yet?
EP22903
Poster Title: Hematopoietic Stem Cell Transplantation: Are We There Yet?
Submitted on 21 Apr 2015
Author(s): Shalmali Pendse, Anuradha Vaidya
Affiliations: Symbiosis School of Biomedical Sciences, Symbiosis International University
This poster was presented at 5th International Conference On Stem Cell and Cancer: Proliferation and Apoptosis (ICSCC)
Poster Views: 3,307
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Poster Information
Abstract: Hematopoietic stem cells (HSCs) have a remarkable potential to self-renew and differentiate into many blood cell types. Self-renewal is the property to retain the stem cell status following cell division whereas differentiation is the property to get committed to a more specific lineage. HSCs have been studied extensively for therapeutic purposes in the treatment of blood diseases, inherited blood disorders, and autoimmune diseases. Today hematopoietic stem cell transplantation (HSCT) is not only an established treatment for various malignant and non-malignant conditions, but it is the only acceptable therapeutic procedure using stem cells.
Thomas et al (1957) were the first to perform allogeneic HSCT to treat a patient suffering from a hematological malignancy. In 1968, severe combined immuno-deficient disease (SCID) patients treated with HSCT were the first reported long term survivors following transplantation using HSCs. The discovery by Till and McCulloch embarked on a new journey towards many investigations to clarify HSC biology, functional characterization, purification, cultivation and other aspects of stem cell research, and HSCT. Simultaneously, the use of various conditioning regimens prior to allogeneic HSCT also improved the probability of long-term remission.
Recently, the concept of using mesenchymal stem cells (MSCs) along with HSCs is becoming a promising factor in improving transplantation success rates. Furthermore, the identification of novel HSC specific markers has proved beneficial in selectively isolating and transplanting HSCs especially in allogeneic transplantation using bone marrow, thereby greatly reducing the chances of graft rejection.
In the poster review we will discuss the various advancements in HSC research and their contributions in improving HSCT outcomes.
Summary: This review poster comprises of the overall development of hematopoietic stem cell transplantation (HSCT) as a therapy for variety of immuno compromised diseases since 1950 till date. It starts with the general information about hematopoietic stem cells, its sources as well as the types of HSCT. It also contains the role of mesenchymal stem cells in HSCT along with its present scenario and it ends with the future directions regarding HSCT.References: 1. Edward A. Copelan. MEDICAL PROGRESS Hematopoietic Stem Cell transplantation. N Engl J Med:354:1813-26, 2006.
2. Marie-Térèse Little and Rainer Storb. History of hematopoietic stem cell transplantation. Nature reviews: volume 2: 231-238, 2001.
3. Arnold I. Caplan. Adult Mesenchymal Stem Cells for Tissue Engineering Versus Regenerative Medicine. Journal of cellular Physiology: 213: 341–347, 2007.
4. Susan A. Ezzone. History of Hematopoietic stem cell transplantation. Seminars in Oncology Nursing, Vol 25, No 2 (May): pp 95-99, 2009
5.takafuni Yokota, Kenji Oritani, Stefan Butz, Stephan Ewers, Dietmar Vestweber and Yuzuru Kanakura. Markers for Hematopoietic Stem Cells: Histories and Recent Achievement. Advances in Hematopoietic Stem Cell Research: 76-88, 2012
6.Anuradha Vaidya and Smita singhania. Quality Control Measures In Cord Blood Bamking In India- Critical Appraisal And Recommendations. Journal of Stem Cells, Volume 8, Number 2
7.Lalit Kumar. Hematopoietic
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