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EP38468
Poster Title: High throughput single-shot proteomics on the timsTOF Pro 2
Submitted on 09 Mar 2022
Author(s): Verena Tellstroem 1, Kristina Marx 1, Dirk Wunderlich 1, Gary Kruppa 2, Nagarjuna Nagaraj 1
Affiliations: 1 Bruker Daltonics GmbH & Co. KG, Bremen, Germany 2 Bruker S.R.O., Brno, Czech Republic
Poster Views: 507
Submitted on 09 Mar 2022
Author(s): Verena Tellstroem 1, Kristina Marx 1, Dirk Wunderlich 1, Gary Kruppa 2, Nagarjuna Nagaraj 1
Affiliations: 1 Bruker Daltonics GmbH & Co. KG, Bremen, Germany 2 Bruker S.R.O., Brno, Czech Republic
Poster Views: 507
Abstract: ▪ Successful proteomics research requires the combination of maximum depth of proteome coverage and quantitative accuracy with sample throughput becoming increasingly important in applications like clinical and personalized medicine proteomics.
▪ TIMS ion mobility separation delivers space and time focusing of ions hereby providing the basis for speed and sensitivity coupled with mobility offset but mass aligned (MOMA) isomeric species separation.
▪ The timsTOF Pro platform powered by PASEF® technology has become a standard in 4D-Proteomics™ delivering accurate in-depth information in a robust fashion and on fast gradients [1,2].
▪ The new timsTOF Pro 2 advances this well-established instrument platform with even better sensitivity, capacity and robustness, delivering high coverage and quantitative precision on even shorter gradients hence, increasing sample throughput.
▪ In this study we demonstrate the benefits of the timsTOF Pro 2 instrument in a label free proteomics study on a cell line and on short LC gradients.Summary: In this study we demonstrate the benefits of the timsTOF Pro 2 instrument in a label free proteomics study on a cell line and on short LC gradients.References: 1: Meier F et al. (2015). J. Proteome Res.
2: Meier F et al. (2018). Molecular & Cellular Proteomics
▪ TIMS ion mobility separation delivers space and time focusing of ions hereby providing the basis for speed and sensitivity coupled with mobility offset but mass aligned (MOMA) isomeric species separation.
▪ The timsTOF Pro platform powered by PASEF® technology has become a standard in 4D-Proteomics™ delivering accurate in-depth information in a robust fashion and on fast gradients [1,2].
▪ The new timsTOF Pro 2 advances this well-established instrument platform with even better sensitivity, capacity and robustness, delivering high coverage and quantitative precision on even shorter gradients hence, increasing sample throughput.
▪ In this study we demonstrate the benefits of the timsTOF Pro 2 instrument in a label free proteomics study on a cell line and on short LC gradients.Summary: In this study we demonstrate the benefits of the timsTOF Pro 2 instrument in a label free proteomics study on a cell line and on short LC gradients.References: 1: Meier F et al. (2015). J. Proteome Res.
2: Meier F et al. (2018). Molecular & Cellular Proteomics
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