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Holistic platform for xenometabolome coverage of zebrafish embryos exposed to triclosan utilizing timsTOFpro and a biotransformation-oriented data processing workflow
EP38414
Poster Title: Holistic platform for xenometabolome coverage of zebrafish embryos exposed to triclosan utilizing timsTOFpro and a biotransformation-oriented data processing workflow
Submitted on 08 Mar 2022
Author(s): Dimitrios E. Damalas1; Elena I. Panagopoulou1; Adamantia Agalou2; Dimitris Beis2; Robert Galvin3; Carsten Baessmann3; Artem Filipenko4; Nikolaos S. Thomaidis1
Affiliations: 1National and Kapodistrian University of Athens, Athens, Greece; 2Biomedical Research Foundation Academy of Athens, Athens, Greece; 3Bruker Daltonis GmbH & Co. KG, Bremen, Germany; 4Bruker Daltonics, Billerica, MA
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Poster Information
Abstract: Triclosan (TCS) constitutes a common household product ingredient, given its antimicrobial activity, and has been widely used over the past decades. There is clear evidence that TCS persists in aquatic systems. Thus, it is urgent to evaluate its potentially toxic effects to aquatic organisms. Zebrafish has emerged as a powerful model organism to study various aspects of developmental and cell biology, while it provides a promising alternative model for acute toxicological studies. The impact of xenobiotics in the aquatic environment is evaluated in more depth when the whole xenometabolome of aquatic organisms is studied. Biotransformation is known to affect the internal concentration (Cint) and the uptake of the parent xenobiotics, while it constitutes a critical factor for the toxic response.Summary: Triclosan (TCS) constitutes a common household product ingredient, given its antimicrobial activity, and has been widely used over the past decades. There is clear evidence that TCS persists in aquatic systems. Thus, it is urgent to evaluate its potentially toxic effects to aquatic organisms.References: Report abuse »
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