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Human iPSC-derived cardiomyocytes: A translational model to predict drug-induced cardiac arrhythmias and long-term toxicity
EP25631
Poster Title: Human iPSC-derived cardiomyocytes: A translational model to predict drug-induced cardiac arrhythmias and long-term toxicity
Submitted on 14 Mar 2017
Author(s): R Kettenhofen1, G Luerman1, R Bucerius1, I Kopljar2, DJ Gallacher2, A De Bondt2, E Vlaminckx2, I Van Den Wyngaert2, HR Lu2, H Bohlen1
Affiliations: 1 Axiogenesis AG, Cologne, Germany; 2 Discovery Sciences, Janssen Research and Development, Janssen Pharmaceutica, Beerse, Belgium Conference Contact: roman.bucerius@axiogenesis.com
This poster was presented at Stem Cells in Drug Discovery
Poster Views: 1,880
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Abstract: Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes represent a promising model for in vitro prediction of cardiac arrhythmias. Currently, two commercially available hiPSC-derived cardioymocyte products - including Axiogenesis Cor.4U human cardiomyocytes - are validated in an international multi-coresite study inside the comprehensive in vitro Pro-arrhythmia (CiPA) consortium. This aims to change the paradigm of safety pharmacological assessment from the assessment of drug interaction with the hERG channel to a potentially clinically more relevant assay system using human iPSC-derived cardiomyocytes in MEA-, voltage- and calcium-sensitive dye recordings.

Besides CiPA, a variety of oncological drugs including tyrosine kinase and HDAC inhibitors have been reported to induce long-term cardiac toxicity in the clinic. Recent findings clearly show that Cor.4U cardioymocytes can be applied to a long-term impedance assay and the results from known drugs perfectly translate to the clinical observations.

The results shown here imply that iPSC-derived Cor.4U human cardioymocytes are a translational in vitro cell model for the prediction of clinically relevant drug-induced cardiac arrhythmias and long-term toxicity.
Summary: The results shown here imply that iPSC-derived Cor.4U human cardioymocytes are a translational in vitro cell model for the prediction of clinically relevant drug-induced cardiac arrhythmias and long-term toxicity.Report abuse »
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