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Humanin nanoparticles for reducing pathological factors characteristic of age-related macular degeneration
Humanin nanoparticles for reducing pathological factors characteristic of age-related macular degeneration
Submitted on 08 Feb 2018

Aum Solanki, Rudy Smalling, Abraham Parola, Ilana Nathan, Yashwant Pathak, Vijaykumar Sutariya
University of South Florida, Ben-Gurion University
This poster was presented at USF Research Day 2018
Poster Views: 292
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Poster Abstract
Humanin is a novel neuronal peptide that has displayed potential in the treatment of Alzheimer’s Disease through the suppression of inflammatory IL-6 cytokine receptors. Such receptors are found throughout the body, including the eye, suggesting its other potential applications. Age-related macular degeneration is the leading cause of blindness in the developing world. There is no cure for this disease, and currents treatments have several negative side effects associated with them, making finding other treatment options desirable. In this study, a more potent humanin derivative, AGA-HNG, was encapsulated in chitosan nanoparticles (NPs) which were characterized for their size, encapsulation efficiency (EE), and drug release. Their ability to suppress VEGF secretion and protect against oxidative apoptosis was studied in vitro using ARPE-19 cells. The chitosan NPs exhibited similar anti-VEGF properties and oxidative protection as the free protein while exhibiting superior pharmaceutical characteristics including biocompatibility and drug release.

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