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Humanin nanoparticles for reducing pathological factors characteristic of age-related macular degeneration
EP26946
Poster Title: Humanin nanoparticles for reducing pathological factors characteristic of age-related macular degeneration
Submitted on 08 Feb 2018
Author(s): Aum Solanki, Rudy Smalling, Abraham Parola, Ilana Nathan, Yashwant Pathak, Vijaykumar Sutariya
Affiliations: University of South Florida, Ben-Gurion University
This poster was presented at USF Research Day 2018
Poster Views: 1,133
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Poster Information
Abstract: Humanin is a novel neuronal peptide that has displayed potential in the treatment of Alzheimer’s Disease through the suppression of inflammatory IL-6 cytokine receptors. Such receptors are found throughout the body, including the eye, suggesting its other potential applications. Age-related macular degeneration is the leading cause of blindness in the developing world. There is no cure for this disease, and currents treatments have several negative side effects associated with them, making finding other treatment options desirable. In this study, a more potent humanin derivative, AGA-HNG, was encapsulated in chitosan nanoparticles (NPs) which were characterized for their size, encapsulation efficiency (EE), and drug release. Their ability to suppress VEGF secretion and protect against oxidative apoptosis was studied in vitro using ARPE-19 cells. The chitosan NPs exhibited similar anti-VEGF properties and oxidative protection as the free protein while exhibiting superior pharmaceutical characteristics including biocompatibility and drug release.Summary: In this study, a more potent humanin derivative, AGA-HNG, was encapsulated in chitosan nanoparticles (NPs) and its efficacy in reducing pathological factors characteristic of AMD was tested in vitro using ARPE-19 cells. References: Ahmadi, F., M. Ghasemi-Kasman, S. Ghasemi, M. G. Tabari, R. Pourbagher, S. Kazemi and A. Alinejad-Mir (2017). "Induction of apoptosis in HeLa cancer cells by an ultrasonic-mediated synthesis of curcumin-loaded chitosan–alginate–STPP nanoparticles." International journal of nanomedicine 12: 8545.
Al Gwairi, O., L. Thach, W. Zheng, N. Osman and P. J. Little (2016). "Cellular and Molecular Pathology of Age-Related Macular Degeneration: Potential Role for Proteoglycans." Journal of Ophthalmology 2016.
Bird, A. C., R. L. Phillips and G. S. Hageman (2014). "Geographic atrophy: a histopathological assessment." JAMA ophthalmology 132(3): 338-345.
Charununtakorn, S. T., K. Shinlapawittayatorn, S. C. Chattipakorn and N. Chattipakorn (2015). "Potential Roles of Humanin on Apoptosis in the Heart." Cardiovascular therapeutics.
Cheng, L., H. Yu, N. Yan, K. Lai and M. Xiang (2017). "Hypoxia-inducible factor-1α target genes contribute to retinal neuroprotection." Frontiers in Cellular
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