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Identification of novel autoantigensin patients with liver autoimmune diseases by Protein MicroArray
EP20379
Poster Title: Identification of novel autoantigensin patients with liver autoimmune diseases by Protein MicroArray
Submitted on 19 Dec 2013
Author(s): C. Zingaretti, M. Arigò, A. Cardaci, A. Sinisi, L. Muratori, P. Colombatto, F. Bonino, P. Invernizzi5, , A.L. Zignego6 MC. Crosti, M. Moro, J. Geginat, Pagani M., R. De Francesco, S. Abrignani. & M. Bombaci
Affiliations: Fondazione INGM, Istituto Nazionale Genetica Molecolare, Milan; Fondazione IRCCS Ospedale Maggiore Policlinico, Milano; Policlinico Sant’Orsola, Bologna; Azienda Ospedaliera Universitaria Pisana,
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Abstract: The characterization of autoimmune disease-specific biomarkers are of primary importance for the development of diagnostic tools and the comprehension of pathogenetic mechanisms leading to autoimmunity. To this aim a protein microarray was employed to analyze serum samples from patients with autoimmune hepatitis (e.g. AIH & PBC) and of healthy as controls. A panel of autoantigens able to discriminate among the groups of patients was identified for potential use as biomarkers.Summary: The characterization of autoimmune disease-specific biomarkers are of primary importance for the development of diagnostic tools and the comprehension of pathogenetic mechanisms leading to autoimmunity. To this aim a protein microarray was employed to analyze serum samples from patients with autoimmune hepatitis (e.g. AIH & PBC) and of healthy as controls. A panel of autoantigens able to discriminate among the groups of patients was identified for potential use as biomarkers.Report abuse »
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