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Immune suppression in the early stage of COVID 19 disease
EP37741
Poster Title: Immune suppression in the early stage of COVID 19 disease
Submitted on 05 Oct 2021
Author(s): Nan Zhang 1 , Siyuan Wang 1 ,Catherine CL Wong 1*,
Affiliations: Center for Precision Medicine Multi Omics Research, Peking University Health Science Center, Peking University, Beijing 100191, China.
Poster Views: 268
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Poster Information
Abstract: COVID-19, the disease caused by infection with the virus SARS CoV 2, has become a worldwide pandemic. As yet, we know very little about this new virus and its pathogenesis. At the beginning of the pandemic, research studies focused on the management and treatment of severe and critical patients. Statistics showed that the elderly, especially those with underlying conditions such as heart disease, lung disease, obesity and diabetes, have the most severe symptoms. As the virus has now spread globally, more information is available about younger infected people in their 30s to 50s. In a growing number of cases, symptoms were expected to improve, but suddenly got worse. Patients can develop acute respiratory distress syndrome (or even die suddenly in a short period of time. This sudden change implies a “two stage” pattern of disease progression, but the underlying mechanisms are unknown. In this work, we apply a mass spectrometry based, data independent acquisition (quantitative proteomic approach to analyze urine samples from COVID-19 infection cases, healthy donors and non-COVID-19 pneumonia cases. We expect our results to provide hints of how the two stage pathogenesis occurs.Summary: In this work, we apply a mass spectrometry based, data independent acquisition (quantitative proteomic approach to analyze urine samples from COVID-19 infection cases, healthy donors and non-COVID-19 pneumonia cases.References: (1) Immune suppression in the early stage of COVID-19 disease. Nat Commun 2020; 11(1):5859.Report abuse »
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