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Implementation of Holistic Glycopeptide PASEF-DDA Data In Diagnostics
Poster Title: Implementation of Holistic Glycopeptide PASEF-DDA Data In Diagnostics
Submitted on 05 Oct 2021
Author(s): Hans JCT Wessels1, Purva Kulkarni1, Fokje Zijlstra1, Merel Post1, Melissa Bärenfänger1, Pierre-Olivier Schmit2, Alain J van Gool1, Dirk J Lefeber1
Affiliations: 1Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud university medical center, Nijmegen, the Netherlands; 2 Bruker Daltonique S.A., Wissembourg, France
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Poster Information
Abstract: • Holistic PASEF-DDA data is of sufficient quality for use in both biomarker research and diagnostics.
• Glycopeptide workflow for diagnosis of congenital disorders of glycosylation will be implemented in clinical care in 2021
• Use of real-time glycopeptide data processing and reporting by GPU-parallelisation will be explored for next generation workflows
Summary: Advantages of holistic PASEF-DDA data acquisition for clinical applications:
- Single data file can be used for both biomarker research and application
- All possible MS1 and MS/MS data is generated for each sample to enable retrospective analysis of novel biomarkers
- Different disease biomarkers can be evaluated by simply exchanging the glycosylation site targets used for targeted feature extraction
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