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Improved Immuno-affinity Enrichment Combined with Trapped Ion Mobility Mass Spectrometry for Significantly Improved PTM Sensitivity
EP38466
Poster Title: Improved Immuno-affinity Enrichment Combined with Trapped Ion Mobility Mass Spectrometry for Significantly Improved PTM Sensitivity
Submitted on 09 Mar 2022
Author(s): Matthew Willetts 1 , Elizabeth Gordon 1 Diego Assis 1 , Barry Zee², Hayley Peckham 2 , Matthew Stokes²
Affiliations: 1 Bruker Daltonics , Billerica, MA USA 2 Cell Signaling Technology, Danvers, MA USA
Poster Views: 483
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Poster Information
Abstract: Post-translational modification of proteins represents an essential mechanism that regulates the function and abundance of proteins and is critical to a wide variety of cell processes such as signal transduction, cell development and mitosis Post-translationally modified peptides are often present in low abundance and there is a need to characterize PTMs from limited starting material.
Here, we combine an improved immuno-enrichment methodology with high sensitivity trapped ion mobility mass spectrometry for improved sensitivity from less starting material.
Summary: Here, we combine an improved immuno-enrichment methodology with high sensitivity trapped ion mobility mass spectrometry for improved sensitivity from less starting material.Report abuse »
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