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Improved sensitivity and higher lipid annotation ID capabilities using a new vacuum insulated heated ESI source
EP38443
Poster Title: Improved sensitivity and higher lipid annotation ID capabilities using a new vacuum insulated heated ESI source
Submitted on 09 Mar 2022
Author(s): Matthias Szesny, Lucy Woods, Sven Meyer, Ansgar Korf, Nikolas Kessler, Aiko Barsch
Affiliations: Bruker Daltonics GmbH & CoKG, 28359 Bremen, Germany
Poster Views: 193
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Poster Information
Abstract: Abundance of lipids in typical samples such as plasma extracts can vary drastically. Therefore, analytical equipment with a high sensitivity and dynamic range is required in lipidomics research. Here, we present results of a new vacuum insulated heated ion source (VIP-HESI) coupled with a timsTOF Pro ion mobility mass spectrometer including trapped ion mobility separation and CCS values.
As part of the evaluation process dilution series of a lipid standard with and without matrix were acquired to assess the limit of detection (LOD) and the dynamic range. In a second experiment, the lipid ID annotation capability was examined using a commercially available serum standard.
All experiments were compared to data which was acquired with the standard Bruker Apollo II source.
Summary: Here, we present results of a new vacuum insulated heated ion source (VIP-HESI) coupled with a timsTOF Pro ion mobility mass spectrometer including trapped ion mobility separation and CCS values. Report abuse »
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