Posters
« Back
In Silico Characterization of Novel PTEN Activators
EP27264
In Silico Characterization of Novel PTEN Activators
Submitted on 12 Feb 2018

Jacob Wilson1, Emily Palumbo2, Fiona Kearns3, Peng Teng1, Prerna Malaney2, Vladimir Uversky1,5, , Jianfeng Cai3, H. Lee Woodcock3, Vrushank Davé2,6
1) Depts. of Molecular Medicine, 2) Depts. of Pathology and Cell Biology, 3) USF Depts. of Chemistry, College of Arts and Sciences, 4) USF College of Pharmacy, 5) USF Health Byrd Alzheimer’s Research Institute, 6) H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612
This poster was presented at USF Health Research Day
Poster Views: 141
View poster »
Poster Abstract
PTEN is a crucial tumor suppressor that is commonly mutated or down-regulated in several diseases, which aberrantly activates oncogenic PI3K/AKT signaling. Chemotherapeutic agents and kinase inhibitors (KIs) have met with off-target effects and chemoresistance. We hypothesize that direct activation of endogenous PTEN will reduce aberrant PI3K signaling and minimize the dose of chemotherapeutic or KIs. We have identified and characterized novel small molecules (γ-AAPeptides), which are the first to directly activate PTEN function. Herein, we have utilized in silico methods to elucidate the interaction between these small molecules and PTEN. Furthermore, we will employ in vitro mutational analysis to corroborate our results of proposed integral residues.Report abuse »
Questions
Ask the author a question about this poster.
Ask a Question »

Creative Commons

Related Posters


High-throughput Carbonic Anhydrase Activity and Inhibitor Screening Assays
Suratna Hazra, Ph.D., Grigoriy Tchaga, Ph.D., and Gordon Yan, Ph.D.

A High-Throughput Assay to Measure Phosphoenolpyruvate Carboxykinase (PEPCK) Activity in Biological Samples
Shunan Li, Ph.D., Keith Cheung, Ph.D. Grigoriy Tchaga, Ph.D. Jianping Xu, Ph.D. and Gordon Yan, Ph.D. Acknowledments: Kyle Schmitt, Ph.D • Tanvi Gangakhedkar • Gustavo Chavarria, Ph.D. • Kwang Kim, Ph.D. • Robert Stephenson, Ph.D. • Hong Qu, Ph.D.

Insights into mechanisms of vascular calcification from human clinical data.
А. Ibragimova, G. Mkrtchyan, A. Zubko, R. Komarov , Z. Malkandueva, A. Shindyapina.

Transesophageal Echo for a Patient With Ehlers-Danlos Syndrome
Randon Ruff

Events of hyperoxia-induced cardiac remodeling varies with length of exposure
Jennifer Leigh Rodgers, Elspeth Foran, Subhra Mohapatra, and Siva Kumar Panguluri