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Intestinal Drug Absorption
Poster Title: Intestinal Drug Absorption
Submitted on 30 Jun 2022
Author(s): Hannah Cole
Affiliations: Creative Bioarray
This poster was presented at Creative Bioarray
Poster Views: 126
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Poster Information
Abstract: The most common preclinical methods currently used throughout the industry are: in vitro methods, for example, Ussing chamber or membrane vesicles based on animal tissue; cell-based assay systems such as Caco-2 cells and Mardin-Darby canine kidney (MDCK); artificial lipid-based systems such as parallel artificial membrane permeability assay (PAMPA) or immobilized artificial membranes (IAM); in vivo methods (animal pharmacokinetic studies); in situ methods (single-pass perfusion); and in silico (computer-aided drug design) methods.
Summary: The most convenient route of drug administration is oral. Along with the presence of proteolytic enzymes in the gastrointestinal tract, the intestinal mucosa represents the main barrier to the absorption of orally administered drugs into the systemic circulation. Report abuse »
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