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 Introducing ExHiBITT – Exploring Host microBIome inTeraction in Twins-, a colon multiomic cohort study
EP30305
Poster Title: Introducing ExHiBITT – Exploring Host microBIome inTeraction in Twins-, a colon multiomic cohort study
Submitted on 27 Jun 2019
Author(s): Marina Mora-Ortiz, Hajir Ibraheim, Ruth C. E. Bowyer, Sarah Metrustry, Nicholas Powell, Jeremy Sanderson, Tim D. Spector, Kerrin S. Small*, Claire J. Steves*
Affiliations: The Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, UK; Experimental Immunobiology, Division of Transplant Immunology and Mucosal Biology, Great Maze Pond, King's College London, SE1 9RT, UK; Department of Gastroenterology, Guy’s & St. Thomas’ Hospitals NHS Foundation Trust, London, United Kingdom
This poster was presented at School of Life Course Sciences Away day and Lecture
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Abstract: The colon is populated by approximately 1012 microorganisms, but the relationships between this microbiome and the host are still not completely understood. The aim of this project is to recruit a twin cohort to study interactions between colon microbiota and host genomics. Here, our objective is to introduce this new cohort called ExHiBITT – Exploring Host microBIome inTeraction in Twins-.
ExHiBITT – Exploring Host microBIome inTeraction in Twins- is a new study which will enable scientist access to a large number of OMICS’ (microbiome, metabolome, genome, transcriptome and inmune system in multiple tissues) data related to the colon. Here, we present the profile study of this cohort. Descriptive and inferential statistics were employed to analyse the colonoscopy traits. Results showed a high concordance ratio for diverticulosis (70%) and polyps (27%). A significant proportion of this apparently normal cohort had colonic polyps (28%), which are of interest as potential precursors of colorectal cancer, and as expected, the number of polyps found was significantly correlated with BMI and age. Further studies will analyse the interactions between the microbiome and the metabolism.
Summary: Introducing ExHiBITT – Exploring Host microBIome inTeraction in Twins-, a colon multiomic cohort studyReferences: N/AReport abuse »
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