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Lipidomics profiling of plasma samples from patients with SARS CoV 2 by timsTOF Pro 2 PASEF
EP38441
Poster Title: Lipidomics profiling of plasma samples from patients with SARS CoV 2 by timsTOF Pro 2 PASEF
Submitted on 09 Mar 2022
Author(s): Jun Yang 1 , Aaron Peng 1 , Xuejun Peng 2 , Lucy Woods 2
Affiliations: 1 UC Davis, Davis CA, 2 Bruker Scientific LLC, San Jose CA, 3 Bruker Scientific LLC, Billerica, MA, USA
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Abstract: The coronavirus disease 2019 (COVID 19) caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV 2) has spread throughout the world. One of the key pathways regulating the immune response to COVID 19 infection is the release of regulatory lipid mediator which leads the dysregulation of lipid metabolism and causes the alteration of blood cholesterol and lipoprotein homeostasis, all suggested lipids can be involved in SARS CoV 2 pathogenesis [ 1 3]. In this work, a non targeted LC timsTOF Pro 2 PASEF lipidomics workflow was performed to profile lipids and their changes within plasma samples.Summary: In this work, a non targeted LC timsTOF Pro 2 PASEF lipidomics workflow was performed to profile lipids and their changes within plasma samples.References: (1) Robert Nardacci et al.; Cell Death and Disease (2021) 12: 263
(2) Marianna Caterino et al.; Nature (2021) 11:2941
(3) Cindy B McReynolds et al.; Frontiers in Physiology (2021) 12: Article 663869
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