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EP31302
Abstract: Lutein is a carotenoid that has been shown to support vision health. Lutein is available in two forms – lutein esters, which is the form naturally found in plants, and free lutein. Both forms have been used for eye support products. In order to assess the relative bioavailability of these two forms, we used an animal model to compare absorption into the blood, and we measured the levels of lutein in plasma as a function of time. The commercial samples of lutein esters and free lutein were made from the same source of oleoresin and in the same form (oil), thus eliminating variability in the source. We found that the bioavailability of lutein esters was significantly greater than that of free lutein, as measured by Area Under The Curve. Bioavailability is an important measure of the efficacy of dietary ingredients.
Summary: This bioavailability study was conducted to assess the relative bioavailability/absorption between lutein esters and free lutein. Lutein esters and free lutein are from the same source of oleoresin derived from marigold flowers. Under these conditions, in an animal model, lutein ester bioavailability was measured to be significantly greater than free lutein bioavailability. Bioavailability is an important measure of the efficacy of dietary ingredients.
References: 1. Gao, Shasha et al. “Lutein and zeaxanthin supplementation reduces H2O2-induced oxidative damage in human lens epithelial cells.” Molecular Vision vol. 17 (2011): 3180-90
2. Widomska J, Zareba M, Subczynski WK. Can Xanthophyll-Membrane Interactions Explain Their Selective Presence in the Retina and Brain? Foods 2016;5(1)
3. https://www.ncbi.nlm.nih.gov/pubmed/7933422
4. Age-Related Eye Disease Study 2 (AREDS2) Research Group (2014). JAMA Ophthalmol. 132: 142-149
5. https://en.wikipedia.org/wiki/Lutein
6. https://academic.oup.com/jn/article/
132/12/3668/4712124
7. https://www.ncbi.nlm.nih.gov/pubmed/
21677121
8. https://www.ncbi.nlm.nih.gov/pubmed/
27273910
9. https://www.excelforum.com/excel-formulas-and-functions/432855-how-do-i-calculate-the-area-under-the-curve-using-excel.html
Summary: This bioavailability study was conducted to assess the relative bioavailability/absorption between lutein esters and free lutein. Lutein esters and free lutein are from the same source of oleoresin derived from marigold flowers. Under these conditions, in an animal model, lutein ester bioavailability was measured to be significantly greater than free lutein bioavailability. Bioavailability is an important measure of the efficacy of dietary ingredients.
References: 1. Gao, Shasha et al. “Lutein and zeaxanthin supplementation reduces H2O2-induced oxidative damage in human lens epithelial cells.” Molecular Vision vol. 17 (2011): 3180-90
2. Widomska J, Zareba M, Subczynski WK. Can Xanthophyll-Membrane Interactions Explain Their Selective Presence in the Retina and Brain? Foods 2016;5(1)
3. https://www.ncbi.nlm.nih.gov/pubmed/7933422
4. Age-Related Eye Disease Study 2 (AREDS2) Research Group (2014). JAMA Ophthalmol. 132: 142-149
5. https://en.wikipedia.org/wiki/Lutein
6. https://academic.oup.com/jn/article/
132/12/3668/4712124
7. https://www.ncbi.nlm.nih.gov/pubmed/
21677121
8. https://www.ncbi.nlm.nih.gov/pubmed/
27273910
9. https://www.excelforum.com/excel-formulas-and-functions/432855-how-do-i-calculate-the-area-under-the-curve-using-excel.html
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