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LYMPHATIC VESSEL DENSITY AS A PROGNOSTIC FACTOR IN ORAL SQUAMOUS CELL CARCINOMA USING D2-40
EP31319
Poster Title: LYMPHATIC VESSEL DENSITY AS A PROGNOSTIC FACTOR IN ORAL SQUAMOUS CELL CARCINOMA USING D2-40
Submitted on 14 Feb 2020
Author(s): Alaa A. Elmorsy1 BDS, Taissir A. Omar2 PhD, Hamed A. Fouad3 PhD, Mohamed M. Fata4 PhD
Affiliations: 1. Instructor in Oral Pathology Department, Faculty of Dentistry, Alexandria University. 2. Professor in Oral Pathology Department. 3. Professor in Oral Pathology Department. 4. Professor in Cranio Maxillofacial and Plastic Surgery
This poster was presented at 2nd annual oral pathology scientific day. Faculty of Dentistry, Cairo University
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Poster Information
Abstract: Oral squamous cell carcinoma (OSCC) accounts for more than 90% of all the oral cancers. Despite the advances in the approach to locally advanced disease, about 50% of the tumors will recur. Fifty percent of the patients present with nodal involvement that is detectable during diagnosis. Of this group, less than 40% survive after five years, compared with a 90% survival rate for patients without metastasis. If the lesion is detected at an early stage and treated effectively, the survival rate could exceed 50%. Lymphatic vessel density (LVD) may be useful for diagnosing and selecting patients who are more susceptible to metastatic spread to undergo elective cervical lymph node dissection. Therefore, it could constitute relevant parameter for determining the prognosis and guiding bio┬Člogical treatments for aggressive OSCC. Summary: OSCCischaracterizedbyahighlocalinvasionrateandcervicalmetastasis.Thepresenceoflymphnodemetastasisatthetimeofdiagnosisisanindicationofpoorprognosis(1).Thedensityoflymphaticvesselscouldplayakeyroleinthedisseminationandmetastasisofcarcinomas(2)References: 1. Kohler HF, Kowalski LP. Prognostic impact of the level of neck metastasis in oral cancer patients. BrazJ Otorhinolaryngol. 2012;78(6):15-20.
2. MashhadiabbasF, MahjourF, MahjourSB, FereidooniF, HosseiniFS. The immunohistochemicalcharacterization of MMP-2, MMP-10, TIMP-1, TIMP-2, and podoplaninin oral squamous cell carcinoma. Oral SurgOral Med Oral PatholOral Radiol. 2012;114(2):240-50.
3.Weidner N, SempleJP, Welch WR, FolkmanJ. Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N EnglJ Med. 1991;324(1):1-8.
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