Posters
« Back
MatriGrid® - Mimicking real organ structures with biolithomorphic processed porous membranes
EP26057
Poster Title: MatriGrid® - Mimicking real organ structures with biolithomorphic processed porous membranes
Submitted on 10 Jul 2017
Author(s): Mai, P.*, Baca, M.*, Borowiec, J.*, Brauer, D.*, Gebinoga, M.*, Hampl, J.*, Schlingloff, G.*, Singh, S.*, Weise, F.*, Behr, R.', Beck, J.", Frey, J.", Voigt, A.", Schober, A.*
Affiliations: * Department of Nano-Biosystem Technology, Ilmenau University of Technology (Germany), ' Degenerative Diseases, German Primate Center, Göttingen (Germany), " Department of Paediatric Haematology and Oncology, Jena University Hospital (Germany)
This poster was presented at Organ-on-a-Chip World Congress & 3D-Culture 2017
Poster Views: 1,116
View poster »


Poster Information
Abstract: Recent ex vivo studies depicted that organ function is not induced of a single cell type but due to a combined effect of cell-cell and cell-environment interactions. To design a useful cell culture models for lap-on-a-chip approaches it is important to replace 2D mono-cultures with 3-dimensional multicellular cell cultures. Such a cell culture technology requires proper methods for processing the cell carrier substrate and controlling cell attachment.
With the aid of biotechnical multiscale engineering the most important geometrical features of a biological morphology can be defined [1]. As a result, individual structures for favored organs can be designed. Due to the combination of different methods of microsystem technology and surface chemistry, so called BioLithoMorphie®, it is possible to transfer these structures to a cell carrier substrate, for example a (bio-) polymer [2, 3].
This procedure enabled the creation of a group of structured cell carriers out of polycarbonate (MatriGrid®), which mimic different organs for the use in drug testing, toxicity testing and stem cell research. MatriGrids are established and tested for liver, brain, heart, bone marrow and testes [4].
Summary: Group of porous membranes (MatriGrids®) which mimic complex organ structures to build up 3-dimensional multicellular cell cultures have been established. These organ-like cell cultures are arranged by biolithomorphic methods, a combination of methods from microsystem technology and surface chemistry.References: [1] “Biotechnical multi-scale engineering mimicking the biological world”, A. Schober, U. Fernekorn, S. Singh, G. Schlingloff, M. Gebinoga, J. Hampl, A. Williamson, , Eng. Life Sci. 2013, 13, 352–367;
[2] "Formkörper zur Nachbildung einer Struktur eines biologischen Gewebes und Verfahren zu dessen Herstellung", Patent application Schober, Hampl et al. DE 10 2014 112 660.2. and WO 2016/034471
[3]. "Biolithomorphische Nachbildung einer Stammzellnische eines Organismus sowie Verfahren zu deren Erzeugung", Patent application Schober, Beck et al. DE 10 2015 108 566.6.
[4] “Development of microstructuring technologies of polycarbonate for establishing advanced cell cultivation systems”, U. Fernekorn, J. Hampl, F. Weise; S. Singh, J. Borowiec, A. Schober; In: Handbook of polymers for pharmaceutical technologies. - Hoboken, New Jersey : John Wiley & Sons, Inc, Bd. 2.2015, S. 67-93
Report abuse »
Questions
Ask the author a question about this poster.
Ask a Question »

Creative Commons

Related Posters


Genetic Engineering in Male Sterility for Hybrid Variety Development
Abir Hasan Joy

Micropillar-assisted electric field enhancement for high-efficiency inactivation of bacteria
S Pudasaini · A. T. K. Perera · S. S. U. Ahmed · Sum Huan Ng · Chun Yang

VITVO: Mimicking In Vivo Complexity By The Innovative 3D Model
Olivia Candini1, Giulia Grisendi1, Elisabetta Manuela Foppiani1, Matteo Brogli1, Beatrice Aramini2, Valentina Masciale3, Carlotta Spano1, Tiziana Petrachi4, Elena Veronesi4, Pierfranco Conte5,6, Giorgio Mari1 & Massimo Dominici1,3

Digiceuticals
Helana Lutfi and Shaban Nuredini

Characterization of patient-derived organoids cultured on a gas-rich, liquid-liquid interface
James T. Shoemaker, Katherine R. Richardson, Jamie Arnst, Adam Marcus, Jelena Vukasinovic