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MatriGrid® - Mimicking real organ structures with biolithomorphic processed porous membranes
EP26057
Poster Title: MatriGrid® - Mimicking real organ structures with biolithomorphic processed porous membranes
Submitted on 10 Jul 2017
Author(s): Mai, P.*, Baca, M.*, Borowiec, J.*, Brauer, D.*, Gebinoga, M.*, Hampl, J.*, Schlingloff, G.*, Singh, S.*, Weise, F.*, Behr, R.', Beck, J.", Frey, J.", Voigt, A.", Schober, A.*
Affiliations: * Department of Nano-Biosystem Technology, Ilmenau University of Technology (Germany), ' Degenerative Diseases, German Primate Center, Göttingen (Germany), " Department of Paediatric Haematology and Oncology, Jena University Hospital (Germany)
This poster was presented at Organ-on-a-Chip World Congress & 3D-Culture 2017
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Poster Information
Abstract: Recent ex vivo studies depicted that organ function is not induced of a single cell type but due to a combined effect of cell-cell and cell-environment interactions. To design a useful cell culture models for lap-on-a-chip approaches it is important to replace 2D mono-cultures with 3-dimensional multicellular cell cultures. Such a cell culture technology requires proper methods for processing the cell carrier substrate and controlling cell attachment.
With the aid of biotechnical multiscale engineering the most important geometrical features of a biological morphology can be defined [1]. As a result, individual structures for favored organs can be designed. Due to the combination of different methods of microsystem technology and surface chemistry, so called BioLithoMorphie®, it is possible to transfer these structures to a cell carrier substrate, for example a (bio-) polymer [2, 3].
This procedure enabled the creation of a group of structured cell carriers out of polycarbonate (MatriGrid®), which mimic different organs for the use in drug testing, toxicity testing and stem cell research. MatriGrids are established and tested for liver, brain, heart, bone marrow and testes [4].
Summary: Group of porous membranes (MatriGrids®) which mimic complex organ structures to build up 3-dimensional multicellular cell cultures have been established. These organ-like cell cultures are arranged by biolithomorphic methods, a combination of methods from microsystem technology and surface chemistry.References: [1] “Biotechnical multi-scale engineering mimicking the biological world”, A. Schober, U. Fernekorn, S. Singh, G. Schlingloff, M. Gebinoga, J. Hampl, A. Williamson, , Eng. Life Sci. 2013, 13, 352–367;
[2] "Formkörper zur Nachbildung einer Struktur eines biologischen Gewebes und Verfahren zu dessen Herstellung", Patent application Schober, Hampl et al. DE 10 2014 112 660.2. and WO 2016/034471
[3]. "Biolithomorphische Nachbildung einer Stammzellnische eines Organismus sowie Verfahren zu deren Erzeugung", Patent application Schober, Beck et al. DE 10 2015 108 566.6.
[4] “Development of microstructuring technologies of polycarbonate for establishing advanced cell cultivation systems”, U. Fernekorn, J. Hampl, F. Weise; S. Singh, J. Borowiec, A. Schober; In: Handbook of polymers for pharmaceutical technologies. - Hoboken, New Jersey : John Wiley & Sons, Inc, Bd. 2.2015, S. 67-93
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