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Mechanistic Prediction of Volume of Distribution: The Influence of Plasma and Tissue Binding
EP20449
Poster Title: Mechanistic Prediction of Volume of Distribution: The Influence of Plasma and Tissue Binding
Submitted on 19 Dec 2013
Author(s): Kiril Lanevskij, Remigijus Didziapetris, Pranas Japertas
Affiliations: ACD Labs
Poster Views: 995
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Poster Information
Abstract: Drug molecules circulate in plasma either free or bound to plasma proteins such as albumin (acidic drugs), a1-acid glycoprotein (basic drugs), lipoproteins (neutral compounds), etc. The extent of plasma protein binding (PPB) is a key determinant of all subsequent distribution processes including CNS permeation, partitioning into tissues, and elimination.
Summary: Plasma protein binding (usually expressed as a percentage bound fraction %PPB) and volume of distribution (Vd) are the two major parameters characterizing drug disposition in the body.
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