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Microarray Analysis Using Competitive Hybridization
EP20361
Poster Title: Microarray Analysis Using Competitive Hybridization
Submitted on 19 Dec 2013
Author(s): J. Bishop, C. Wilson, A. M. Chagovetz and S. Blair
Affiliations: University of Utah
Poster Views: 1,463
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Poster Information
Abstract: In this work we explore the effects of wild-type and single nucleotide polymorphism (SNP) target specie concentrations, temperature, and the time of hybridization on sensing specificity in two component systems. A finite element method is used to simulate the diffusion of DNA through a microfluidic chamber to the sensing surface of bound oligonucleotide probes where hybridization of DNA is modeled using the corresponding chemical reaction equation assuming low grafting density.Summary: In this work we explore the effects of wild-type and single nucleotide polymorphism (SNP) target specie concentrations, temperature, and the time of hybridization on sensing specificity in two component systems. A finite element method is used to simulate the diffusion of DNA through a microfluidic chamber to the sensing surface of bound oligonucleotide probes where hybridization of DNA is modeled using the corresponding chemical reaction equation assuming low grafting density.Report abuse »
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