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MODEL-AD: Genetic models of late-onset Alzheimer’s disease
EP26690
Poster Title: MODEL-AD: Genetic models of late-onset Alzheimer’s disease
Submitted on 21 Nov 2017
Author(s): *A. OBLAK1,2, G. CARTER3, G. R. HOWELL3, B. LOGSDON4, L. MANGRAVITE4, K. NHO2, L. OMBERG4, K. D. ONOS3, V. PHILIP3, C. PREUSS3, S. J. SUKOFF RIZZO3, M. SASNER3, L. SHEN1,2, A. J. SAYKIN1,2, P. TERRITO1,2, A. UYAR3, H. WILLIAMS3, B. T. LAMB1,5
Affiliations: 1STARK Neurosci. Res. Inst., 2Radiology & Imaging Sciences, Indiana University School of Medicine, 3The Jackson Lab., Bar Harbor, ME; 4Sage Bionetworks, Seattle, WA; 5Medical & Molecular Genetics, Indiana University School of Medicine
This poster was presented at Society for Neuroscience 2017
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Poster Information
Abstract: Alzheimer’s disease (AD) is the most common form of dementia, with no effective preventative strategies or treatments. One of the major obstacles of developing novel therapies for AD is the lack of predictive animal models to be used in preclinical trials of therapeutics. One reason for this may
be that existing models are based on familial mutations, while the vast majority of the clinical population has non-familial late-onsetAD (LOAD). The Model Organism Development and Evaluation for Late-onset AD (MODEL-AD) Center has been established as a consortium consisting of IndianaUniversity, TheJacksonLaboratory, and Sage Bionetworks. The goals of the Center are: to identify novel genetic variants, genes and biomarkers from AD patient data; to generate and validate new animal models based on these LOAD variants; and to utilize these novel models in a preclinical testing paradigm.
Summary: A brief overview into the Model Organism Development and Evaluation of Late Onset Alzheimer's Disease center and future goals.Report abuse »
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