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Modeling Disposition of Sotalol following Intravenous and Oral Administration in Healthy Adult Subjects
EP20511
Poster Title: Modeling Disposition of Sotalol following Intravenous and Oral Administration in Healthy Adult Subjects
Submitted on 20 Dec 2013
Author(s): S. Ray Chaudhuri, V. Lukacova and W. S. Woltosz
Affiliations: Simulations Plus
Poster Views: 1,674
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Poster Information
Abstract: Sotalol is a non specific adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmia. Its absorption, distribution and systemic PK or, collectively, ‘disposition’ was modeled and simulated using GastroPlus™ v7.0. Biopharmaceutical properties were obtained from in silico predictions and in vitro measurements.Summary: Sotalol is a non specific adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmia. Its absorption, distribution and systemic PK or, collectively, ‘disposition’ was modeled and simulated using GastroPlus™ v7.0. Biopharmaceutical properties were obtained from in silico predictions and in vitro measurements.Report abuse »
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