Posters
« Back
Modeling Drug Disposition of Timolol in Ocular Tissues of Rabbit following Topical Eye Drops
EP20415
Poster Title: Modeling Drug Disposition of Timolol in Ocular Tissues of Rabbit following Topical Eye Drops
Submitted on 19 Dec 2013
Author(s): S. Ray Chaudhuri, V. Lukacova, W.S. Woltosz
Affiliations: Simulations Plus Inc.
Poster Views: 999
View poster »


Poster Information
Abstract: Recently, we reported the successful application of a novel mathematical model describing drug disposition in eye compartments to simulate disposition of clonidine after topical (eye drop) administration. This example extends the methodology to describe the disposition of timolol in different eye tissues and plasma after topical administration. Timolol is a nonselective beta-adrenoceptor antagonist used to lower intraocular pressure (IOP). A serious disadvantage of ocular timolol therapy is the amount of drug getting into systemic circulation that adversely affects vital organ functions in elderly patients.Summary: A serious disadvantage of ocular timolol therapy is the amount of drug getting into systemic circulation that adversely affects vital organ functions in elderly patients.Report abuse »
Creative Commons

Related Posters


Clinical and Scientific Evidence for the Safety and Efficacy of XanMax® Lutein/Zeaxanthin
Priya, M.K., Lelah, M.

Lutein Esters are more Bioavailable than Free Lutein
Michael Lelah

Primary Human Hepatocytes 3D in vitro Culture Model for Studying Hepatic Function
Sujoy Lahiri, Julia Tritapoe, Kate Comstock, Michael F. Millett, Mark Kennedy, Theresa V. Nguyen, Deborah K. Tieberg, David T. Kuninger

VITVO: Mimicking In Vivo Complexity By The Innovative 3D Model
Olivia Candini1, Giulia Grisendi1, Elisabetta Manuela Foppiani1, Matteo Brogli1, Beatrice Aramini2, Valentina Masciale3, Carlotta Spano1, Tiziana Petrachi4, Elena Veronesi4, Pierfranco Conte5,6, Giorgio Mari1 & Massimo Dominici1,3

Characterization of patient-derived organoids cultured on a gas-rich, liquid-liquid interface
James T. Shoemaker, Katherine R. Richardson, Jamie Arnst, Adam Marcus, Jelena Vukasinovic