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Modeling Sundowning Syndrome in Mouse Models of Alzheimer
EP27319
Poster Title: Modeling Sundowning Syndrome in Mouse Models of Alzheimer's Disease
Submitted on 22 Feb 2018
Author(s): S. NAGARAJ, A. YUNUS, H MAHONEY, J GAMSBY, D. GULICK
Affiliations: Mol. Med., USF Health Morsani College of Medicine, Tampa, FL
This poster was presented at USF Research Day
Poster Views: 647
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Poster Information
Abstract: Sundowning Syndrome (SS) is a significant constellation of circadian expressed symptoms found in Alzheimer’s disease (AD) that devastates patients as well as placing increased burden caregivers. Current treatment options are scant. Here, we use two distinct mouse models of SS to study whether an inhibitor of casein kinase 1 epsilon delta (CK1ε/δ) can improve circadian rhythmicity and behavior. CK1ε/δ are key regulators of the biological clock. Our models of SS are aged C57BL/6J mice which is a model of aging, and a model of amyloid precursor protein pathology: the APP/PS1 mice, both of which show symptoms characteristic of SS. Using measurement of wheel running and drinking behavior we can assess the recovery of circadian activity patterns. Using a series of behavioral tests at multiple time points we can measure the change in cognitive performance. The CK1ε/δ inhibitor has shown success in recovering circadian rhythm in the mouse models that show dysfunctional patterns of circadian rhythmicity. Continuing behavior experiments are characterizing the changes in cognitive function of mouse models of SS in a circadian fashion that administration of the drug engenders. The results show that directly manipulating effectors of the biological clock provides a novel means of treating SS and improving the lives of AD patients as well as their caregivers.Summary: We have found ways in which modulating the circadian clock can have impacts in neurodegenerative disease, raising potential for therapeutic use in circadian expressed symptom control. Report abuse »
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