Posters
« Back
Molecular Dynamics Simulation Study of Pulmonary Surfactant Interacting With Nanoparticles
EP20582
Poster Title: Molecular Dynamics Simulation Study of Pulmonary Surfactant Interacting With Nanoparticles
Submitted on 20 Dec 2013
Author(s): Syed Kashif Zafar, Syed Tarique Moin and Zaheer-ul-Haq
Affiliations: University of Karachi
Poster Views: 2,976
View poster »


Poster Information
Abstract: Dipalmitoylphospatidylcholine (DPPC) a phospholipid, is the main component of the lung pulmonary surfactant. Components of pulmonary surfactant including dipalmitoylphosphatidic acid (DPPA), dipalmitoylphosphatidyl ethanolamine (DPPE), dimyristoylphospatidylcholine (DMPC) and possibly lung pulmonary surfactant proteins are expected to play a significant role in the biological mechanism of defense against quartz cytotoxicity. Interactions of powder crystalline silica with biological systems cause cell damage, inflammation, and apoptosis. Unfortunately, mechanisms involved in these diseases are still unknown. Currently, molecular dynamics (MD) simulation of phospholipid bilayer are widely used to study the physicochemical properties of pure bilayers, composite bilayers, lipid rafts, cellular processes such as signaling and transport, permeation of water. Silica dust particles in the form of quartz (but not kaolin) have been hypothesized to promote pulmonary diseases such as silicosis. An exact mechanism of silica cytotoxicity at the molecular level is still unknown. It is known that silanol groups on crystalline silica are lethal while amorphous silica and silica in phyllosilicates (e.g., kaolinite) cause virtually no long-term adverse effects. Our 5ns MD simulation studies using NAMD of lipid bilayers supported on alpha-quartz (nanoparticles) and kaolinite with explicit water molecules will be presented to understand the physiochemical effects of nanoparticles on pulmonary surfactant.Summary: MD simulation studies using NAMD of lipid bilayers supported on alpha-quartz (nanoparticles) and kaolinite with explicit water molecules will be presented to understand the physiochemical effects of nanoparticles on pulmonary surfactant.Report abuse »
Creative Commons

Related Posters


Genomics Transforms the Future of Agriculture
CD Genomics

Nanoparticle Drug Delivery Methods via DNA Nanotechnology
Katie Lamar, Autumn Awbrey,Kobe Hassenzahl, Dina Ibrahimzade, Matthew Laurence, Aakash Ramachandran, Massimiliano de Sa, Maureen Muñoz, Thalia Georgiou

Nanomaterials
Tylor Keller

Delivery of RNP complexes for CRISPRi (dCas9) silencing in vitro and in vivo using crystalline ultrasmall particles (CUSP)
GM Unger*, VL Korman, BT Kren, DL Tobolt

Genetic Engineering in Male Sterility for Hybrid Variety Development
Abir Hasan Joy