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Morphohistometric Analysis of the Effects of Coriandrum Sativum on Neurotoxicity
EP37256
Poster Title: Morphohistometric Analysis of the Effects of Coriandrum Sativum on Neurotoxicity
Submitted on 15 May 2021
Author(s): Hesham N. Mustafa
Affiliations: Anatomy Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia., Saudi Arabia
This poster was presented at Focus on Microscopy 2021, P2-E/2
Poster Views: 198
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Poster Information
Abstract: Natural compounds can act as metal chelators and oxygen free radical
scavengers, which allows them to be used as bioactive antagonists’ heavy
metals neurotoxicity. The aim of the study to analyze the morphometric
effects of coriandrum sativum on Lead induced neurotoxicity. Forty SpragueDawley albino rats were divided into four equal groups (ten rats in each
group): control group; coriander group: received aqueous coriandrum
sativum extracts daily (600 mg/kg BW /60 days orally); Pb group: received a
daily dose of lead acetate (Pb) (10 mg/kg BW /60 days orally); Pb +
coriandrum group: received: aqueous coriandrum sativum extract (600
mg/kg BW) prior to 10 mg/kg BW of Pb. The data exhibited an increase in
oxidative stress markers MDA levels and a decrease in the antioxidant
enzymes activities (SOD, CAT, GPx) in Pb group and these effects were
reversed with coriandrum sativum co-administration. The cerebellar cortex
and all layers of the somatosensory cortex thickness and density of nuclei
were diminished. The morphometrical measurements were corrected with
coriandrum sativum. From the findings of the current study, coriandrum
sativum corrected the structural and functional variations in the cerebellar
cortex and somatosensory cortex as it possesses chelating and antioxidant
potentials. This work agreed with the previous reports that propose the
defensive properties of coriandrum sativum on Pb deposition [1, 2]. Aqueous
extracts of coriandrum sativum produced a good significant variation in most
of the evaluated parameters (oxidative stress marker, antioxidants enzymes
and histological alternations) and slow down the oxidative damage induced
by Pb toxicity
Summary: Natural compounds can act as metal chelators and oxygen free radical
scavengers, which allows them to be used as bioactive antagonists’ heavy
metals neurotoxicity. The aim of the study to analyze the morphometric
effects of coriandrum sativum on Lead induced neurotoxicity. Forty SpragueDawley albino rats were divided into four equal groups (ten rats in each
group): control group; coriander group: received aqueous coriandrum
sativum extracts daily (600 mg/kg BW /60 days orally
References: 1. Velaga, M.K., et al., Hydroalcoholic seed extract of Coriandrum sativum (Coriander) alleviates lead-induced oxidative stress in
different regions of rat brain. Biol Trace Elem Res, 2014. 159(1-3): p. 351-63.
2. Tellez-Lopez, M.A., et al., Evaluation of the Chelating Effect of Methanolic Extract of Coriandrum Sativum and Its Fractions on
Wistar Rats Poisoned with Lead Acetate. Afr J Tradit Complement Altern Med, 2017. 14(2): p. 92-102.
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