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Medical Student: Move over Stem Cells – Exosomes are Here! What are Exosomes and their role in Regenerative Medicine?
EP30804
Poster Title: Medical Student: Move over Stem Cells – Exosomes are Here! What are Exosomes and their role in Regenerative Medicine?
Submitted on 15 Oct 2019
Author(s): Amartej Singh Deol MD4;Shivinder S. Deol MD
Affiliations: Anti-Aging & Wellness Center
Poster Views: 147
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Poster Information
Abstract: Stem cells (SC) play a crucial role in all stages of human development from early embryogenesis to regeneration and maintenance in adult life. SC mediate their influence on distal tissues through paracrine secretions of multiple factors rather than local engraftment.

It is known that all cells secrete several chemicals in bodily fluids initially thought to be waste products and cell debris. Now it is believed that these secretions or Extracellular Vesicles (EVs) especially from SC carry out crucial cell-to-cell communications, as well as surveillance and immune functions. EVs carry no cellular material and include Apoptotic Bodies (ABs), Microvesicles, Multivesicular Body (MVB) and Exosomes (Ex). Ex are membrane-bound nanovesicles measuring 30–150 nm, and do not get blocked even in distal capillaries (measure 5-10 μm), whereas SC (measure 10-30 μm) have risk of microvascular occlusions.

Ex carry packets of information including signaling lipids, proteins, micro RNAs, and messenger RNAs which are incorporated by target cells. Ex have key physiological functions with pivotal role in tissue injury regeneration. Ex also have pathological actions when secreted by tumor or older damaged cells, causing expansion and progression of diseases including neurodegenerative diseases.

In my research, I reviewed hypoxic placental mesenchymal stem cells (MSC) Ex ultra-centrifuged to remove all particles over 200 nm. These highly purified MSC-Ex produced high amounts of mRNA, cytokines, and growth factors, and have been used in multiple regenerative conditions with promising results. The lack of side effects and ease of use may make MSC-Ex a good choice in regenerative medicine.
Summary: In my research, I reviewed hypoxic placental mesenchymal stem cells (MSC) Ex ultra-centrifuged to remove all particles over 200 nm. These highly purified MSC-Ex produced high amounts of mRNA, cytokines, and growth factors, and have been used in multiple regenerative conditions with promising results. The lack of side effects and ease of use may make MSC-Ex a good choice in regenerative medicine.References: 1. Centers for Disease Control and Prevention (CDC). "National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011." Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention 201.1 (2011).
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