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N-Terminal Protein Sequencing
Poster Title: N-Terminal Protein Sequencing
Submitted on 25 Aug 2020
Author(s): Creative Proteomics
Affiliations: Creative Proteomics
Poster Views: 71
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Poster Information
Abstract: The N-terminus is the start of a protein or polypeptide. It influences the subcellular distribution, degradation, and the turnover rate of a protein. Therefore, the N-terminal sequence analysis of a protein is important for protein
function study. In addition, in pharmaceutical proteins, there are some often observed variations of N-terminus, including incomplete processing of the N-terminal signal sequences, the formation of pyroglutamate, and the lack of removal of the N-terminal methionine residue. Therefore, N-terminal sequencing is an important quality control analysis. The N terminal sequence confirmation of drug substance is also required by the ICH Q6B.
Summary: Creative Proteomics can provide N-terminal sequencing by Edman degradation or mass spectrometry (MS), with complementary advantages to each other. We can provide N-terminal sequence analysis of peptides, therapeutic proteins, monoclonal antibodies, and protein vaccines. References: abuse »
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