« Back
Nanoparticles designed for intranasal delivery of siRNA and DNA to brain
Nanoparticles designed for intranasal delivery of siRNA and DNA to brain
Submitted on 08 Feb 2018

Vasyl Sava
University of South Florida
This poster was presented at USF Research day 2018
Poster Views: 274
View poster »
Poster Abstract
The overall objective was to develop a nanocarrier system for non-invasive delivery to brain of molecules useful for gene therapy. Following intranasal instillation, Mn-contained nanoparticles (mNP) loaded with DNA or siRNA enhanced 7T MRI images throughout the brain at 24 and 48 hrs. Also, mNPs were shown to be effective in significantly reducing GFP mRNA expression in Tg GFP+ mice in olfactory bulb, striatum, hippo-campus and cortex. This approach for delivery of gene therapies will have a significant impact on disease-modifying therapeutics of neurodegenerative diseases.
Report abuse »
Ask the author a question about this poster.
Ask a Question »

Creative Commons

Related Posters

Improved Expansion of Neural Stem Cells with Gibcoâ„¢ Heat Stable Recombinant Human Basic Fibroblast Growth Factor
Brittany Balhouse, Diana Navarro, Richard Josephson, and Matthew Dallas

Stanley Meyer Designs
Daniel Donatelli

Endocrine Disruptors and Impact of Nutritional Intervention on Hypothyroid Women - A Study in Kolkata
Swapan Banerjee

Strategies for High-Titer Protein Expression Using the ExpiCHO and Expi293 Transient Expression Systems
Chao Yan Liu, Jian Liu, Wanhua Yan, Kyle Williston, Katy Irvin, Henry Chou, Jonathan Zmuda

A Chemically-Defined Baculovirus-Based Expression System for Enhanced Protein Production in Sf9 Cells
Maya Yovcheva, Sara Barnes, Kenneth Thompson, Melissa Cross, Katy Irvin, Mintu Desai, Natasha Lucki, Henry Chiou, Jonathan Zmuda