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Novel Nucleosomics Serum Biomarkers for the Detection of Colorectal Cancer
EP20689
Poster Title: Novel Nucleosomics Serum Biomarkers for the Detection of Colorectal Cancer
Submitted on 23 Dec 2013
Author(s): S Holdenrieder, Y Dharuman, J Standop, M Herzog, N Trimpop, K Hettwer, K Simon, Steffen Uhlig and Jake Micallef
Affiliations: Volition RX
Poster Views: 2,014
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Poster Information
Abstract: This poster reports a study of the prevalence of genome wide epigenetic signals present in circulating cell-free nucleosomes as potential serum biomarkers for colorectal cancers.Summary: As colorectal cancers are often detected at late tumor stages when prognosis of the patients is poor, powerful blood-based biomarkers are needed for earlier detection. In recent years it has become clear that epigenetic changes to chromatin and its constituent nucleosomes are associated with carcinogenesis and elevated levels of nucleosomes are present in the blood of cancer patients.
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