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EP20608
Abstract: This poster reports a remarkable overlap between proteins commonly identified as changing in 2D-GE proteomic studies and those found to change post-mortem. Proteins with one or more phosphorylation sites are of particular interest since they appear to be overrepresented in this group.
The approach detailed may help differentiate true biomarkers from those proteins found in any situation where cells are under stress.Summary: Tissue sampling is a major traumatic event that can have drastic effects within a very short timeframe at the molecular level resulting in loss of sample quality due to post sampling changes. It has recently been reported that the same proteins, regardless of tissue origin or species, are often found expressed differentially in various disease states, bringing into question the significance of these proteins as biomarkers.
The approach detailed may help differentiate true biomarkers from those proteins found in any situation where cells are under stress.Summary: Tissue sampling is a major traumatic event that can have drastic effects within a very short timeframe at the molecular level resulting in loss of sample quality due to post sampling changes. It has recently been reported that the same proteins, regardless of tissue origin or species, are often found expressed differentially in various disease states, bringing into question the significance of these proteins as biomarkers.
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