« Back
Peripheral Opioid Receptor Antagonists Decrease Post-operative Ileus While Sparing Analgesic Efficacy
Peripheral Opioid Receptor Antagonists Decrease Post-operative Ileus While Sparing Analgesic Efficacy
Submitted on 21 Apr 2018

Nastassia Baltodano
Nova Southeastern University
This poster was presented at American Academy of Anesthesiologist Assistants
Poster Views: 532
View poster »
Poster Abstract
The purpose of opioids is to diminish the signaling of pain reception to the brain from nociceptors. While these analgesic properties offer post-operative pain relief, negative side effects such as chronic dependency with the risk of withdrawal as well as opioid induced constipation occur. Innovative research has produced drugs such as methylnaltrexone and alvimopan, which are mu opioid receptor antagonist, that can be coupled with opioids to attenuate possible side effects. With adverse effects being greatly diminished, the beneficial analgesics properties of administering opioids can be sustained by restricting its viability solely within the central nervous system.

Loss of [mu] opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia. Nature Medicine, 23(2), 164-173. Retrieved 10 13, 2017, from
Linn, A. J., & Steinbrook, R. A. (2007). Peripherally restricted μ-opioid receptor antagonists: a review. Techniques in Regional Anesthesia and Pain Management, 11(1), 27-32. Retrieved 10 13, 2017, from
Vanderah, T. W. (2010). Delta and kappa opioid receptors as suitable drug targets for pain. The Clinical Journal of Pain, 26(1). Retrieved 10 13, 2017, from
Viscusi, E. R., Gan, T. J., Leslie, J. B., Foss, J. F., Talon, M., & Du, W. (2009). Peripherally Acting Mu-Opioid Receptor Antagonists and Postoperative Ileus: Mechanisms of Action and Clinical Applicability. Anesthesia & Analgesia, 108(6), 1811-1822. Retrieved 10 13, 2017, from https://n
Report abuse »
Creative Commons

Related Posters

A Novel Enzymatic Assay for Determination of Phosphatidylinositol in Biological Samples
Paul Templeton, Kyle C. Schmitt, Grigoriy Tchaga,and Gordon Yan

A Novel Method For Discovery of Peripheral Blood Biomarkers in Idiopathic Pulmonary Fibrosis Using Extensive Depletion and TMTcalibratorTM Tissue-Enhanced Plasma Proteomics
I. Pike1, M. Bremang1, P.J. Wolters 2, R. Gaster3, S. Turner3, M. Decaris3

Nikita Gandotra

Things just keep changing: Family caregivers' perceptions of the impact of Huntington's disease on caregiver burden
Jess Kaplonyi, Dr Christopher Lind, Catherine Christian, Irene Scott

The EurOPDX EDIReX project: towards a European Research Infrastructure on patient-derived cancer models
E. Vinolo 1, J.P. Morris 1, D.G. Alférez 2, J. Arribas 3,4,5, C. Bernadó 3,4,5, A. Bertotti 6, A. Bruna 7, A.T. Byrne 8, C. Caldas 7, R.B. Clarke 2, N. Conte 9, R. Corsi 10, S. Corso 6, M. Crespo 3, A. Dahmani 11, V. Dangles-Marie 11, D. Decaudin 11, Z. Dudová 12, A. Fiori 6, S. Giordano 6, M. Hauptsmann 13, M. Hidalgo 14, C. Isella 6, S. de Jong 15, J. Jonkers 13, A. Křenek 12, O. Krijgsman 13, D. Kouřil 12, J.C. Lacal 14, L. Lanfrancone 16, E. Leucci 17, G.M. Mælandsmo 18, E. Marangoni 11, J. Mason 9, M.Th. Mayrhofer 19, A. Mazzocca 6, T.S. Meehan 9, E. Montaudon 11, F. Nem