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Peripheral Opioid Receptor Antagonists Decrease Post-operative Ileus While Sparing Analgesic Efficacy
EP27450
Peripheral Opioid Receptor Antagonists Decrease Post-operative Ileus While Sparing Analgesic Efficacy
Submitted on 21 Apr 2018

Nastassia Baltodano
Nova Southeastern University
This poster was presented at American Academy of Anesthesiologist Assistants
Poster Views: 178
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Poster Abstract
The purpose of opioids is to diminish the signaling of pain reception to the brain from nociceptors. While these analgesic properties offer post-operative pain relief, negative side effects such as chronic dependency with the risk of withdrawal as well as opioid induced constipation occur. Innovative research has produced drugs such as methylnaltrexone and alvimopan, which are mu opioid receptor antagonist, that can be coupled with opioids to attenuate possible side effects. With adverse effects being greatly diminished, the beneficial analgesics properties of administering opioids can be sustained by restricting its viability solely within the central nervous system.


Loss of [mu] opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia. Nature Medicine, 23(2), 164-173. Retrieved 10 13, 2017, from https://ncbi.nlm.nih.gov/pubmed/28092666
Linn, A. J., & Steinbrook, R. A. (2007). Peripherally restricted μ-opioid receptor antagonists: a review. Techniques in Regional Anesthesia and Pain Management, 11(1), 27-32. Retrieved 10 13, 2017, from http://sciencedirect.com/science/article/pii/s1084208x07000043
Vanderah, T. W. (2010). Delta and kappa opioid receptors as suitable drug targets for pain. The Clinical Journal of Pain, 26(1). Retrieved 10 13, 2017, from https://ncbi.nlm.nih.gov/pubmed/20026960
Viscusi, E. R., Gan, T. J., Leslie, J. B., Foss, J. F., Talon, M., & Du, W. (2009). Peripherally Acting Mu-Opioid Receptor Antagonists and Postoperative Ileus: Mechanisms of Action and Clinical Applicability. Anesthesia & Analgesia, 108(6), 1811-1822. Retrieved 10 13, 2017, from https://n
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