Abstract: The two-compartment pharmacokinetic model described the mechanisms how human body handles with ingestion of NC-cyclodextrin complexes in gastrointestinal tract (GI), distribution in the blood (Plasma), and their metabolism in the liver. The model showed that drug bioavailability was significantly improved after oral administration of cyclodextrin complexes. The mathematical significance of this study to predict nicardipine delivery using pharmacokinetic two-compartment mathematical model and linear ordinary differential equations approach represents a valuable tool to emphasize its effectiveness and diminish the side effects.Summary: The dispersion routes of cyclodextrin complexes with nicardipine (NC), such as hydrophilic hydroxypropyl-ß-cyclodextrin (NC/HPßCD) and hydrophobic triacetyl-ß-cyclodextrin (NC/TAßCD), through the body for controlled drug delivery and sustained release have been examined.
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