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Plasma proteomic profiling one year postpartum of women with Pre-eclampsia shows dysregulated cardiometabolic profile
EP29894
Poster Title: Plasma proteomic profiling one year postpartum of women with Pre-eclampsia shows dysregulated cardiometabolic profile
Submitted on 01 Apr 2019
Author(s): Fatma S. Abad, Antigoni Manousopoulou, Diana J. Garay-Baquero, Brian R. Birch, Bas B. van Rijn, Spiros D. Garbis and Bashir A. Lwaleed
Affiliations: UNIVERSITY OF SOUTHAMPTON
Poster Views: 270
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Poster Information
Abstract: Abstract
Background: Emerging epidemiological data suggest that pre-eclampsia (PE) is associated with long-term complications, including a two-to four- fold increased risk of cardiovascular disease. The aim of the present study was to examine the global plasma proteomic profile one year postpartum of women with PE during pregnancy, in order to identify which processes are dysregulated.
Methods: Non-depleted plasma collected one year postpartum from women with PE (n=5) and age-matched, BMI-matched women with normal pregnancy (n=5) was analysed using quantitative proteomics.
Results: Principal component analysis of all identified proteins showed that women with PE during pregnancy had a distinct plasma proteomic profile one-year postpartum compared to the control group. One-hundred and seventy two proteins were differentially expressed in the PE vs. control. Gene ontology analysis using DAVID showed that terms related to Inflammatory | Immune response, Blood coagulation and Metabolism were significantly enriched.
Conclusions: The identified proteins could provide insight into the long-term dysregulated cardiometabolic profile of women with PE




Summary: This study reports the most comprehensive to date plasma proteomic profiling one-year postpartum of women with pre-eclampsia compared to controls. The study results show that inflammation | immune response, blood coagulation and metabolism are dysregulated processes one year post-delivery in women with a history of pre-eclampsiaReferences: Chesley LC, Annitto JE and Cosgrove RA (1976) The remote prognosis of eclamptic women: Sixth periodic report. American journal of obstetrics and gynecology 124(5): 446-459.

Chen CW, Jaffe IZ and Karumanchi SA (2014) Pre-eclampsia and cardiovascular disease. Cardiovascular Research 101(4): 579-586


Bellamy L, Casas J-P, Hingorani AD and Williams DJ (2007) Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ : British Medical Journal 335(7627): 974-974.

Al-Daghri NM, Alokail MS, Manousopoulou A, Heinson A, Al-Attas O, Al-Saleh Y, Sabico S, Yakout S, Woelk CH, Chrousos GP and Garbis SD (2016) Sex-specific vitamin D effects on blood coagulation among overweight adults. European journal of clinical investigation 46(12): 1031-1040.

Larkin SE, Johnston HE, Jackson TR, Jamieson DG, Roumeliotis TI, Mockridge CI, Michael A, Manousopoulou A, Papachristou EK, Brown MD, Clarke NW, Pandha H, Aukim-
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