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Polymerized Poly(ethylene glycol) Diacrylate Microfluidic Membrane Valves
EP21773
Poster Title: Polymerized Poly(ethylene glycol) Diacrylate Microfluidic Membrane Valves
Submitted on 06 Mar 2014
Author(s): Chad I. Rogers, Joseph B. Oxborrow, Long-Fang Tsai, Gregory P. Nordin, and Adam T. Woolley
Affiliations: Departments of Chemistry and Biochemistry and Electrical and Computer Engineering, Brigham Young University, Provo, Utah, USA
This poster was presented at Pittcon 2014
Poster Views: 1,722
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Poster Information
Abstract: Polymerized poly(ethylene glycol) diacrylate (poly-PEGDA) was fabricated into pneumatically controlled, non-elastomeric membrane valves as a nonspecific adsorption resistant alternative to polydimethylsiloxane valves. Temporal response, valve closure, and long-term durability of these poly-PEGDA valves were evaluated. Valve operation up to 8 Hz was achieved with a ~100 ms opening time (without applied vacuum) and a ~20 ms closure time. Valve closure demonstrates less leakage in geometries with a larger membrane contact area (>0.3 mm2) and pedestals wider than 15 μm. After ~1000 actuations to reconfigure polymer chains and increase membrane elasticity, the fluid pressure needed to open a closed valve becomes the same as the applied control pressure. After this initial conditioning, the poly-PEGDA valves maintain a linear relationship between the closure pressure and the opening pressure required to initiate flow even after 115,000 actuations. These robust valves have potential for application as peristaltic pumps and in small volume bioassays or impedance detection.Summary: Polymerized poly(ethylene glycol) diacrylate (poly-PEGDA) was fabricated into pneumatically controlled, non-elastomeric membrane valves as a nonspecific adsorption resistant alternative to polydimethylsiloxane valves. Temporal response, valve closure, and long-term durability of these poly-PEGDA valves were evaluated.
References: 1. Rogers et al., Sens. Actuators B 2014, 191, 438-444
2. Rogers et al., Anal. Chem. 2011, 83 (16), 6418-6425
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