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POSSIBLE MECHANISM FOR COMBATING 2019-NOVEL CORONA VIRUS INFECTION
EP31435
Poster Title: POSSIBLE MECHANISM FOR COMBATING 2019-NOVEL CORONA VIRUS INFECTION
Submitted on 20 Mar 2020
Author(s): gagandeep chopra, sonia pahuja, prerna sarup
Affiliations:
This poster was presented at international conference on drug development
Poster Views: 1,560
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Poster Information
Abstract: There is a large family of virus that causes illness from common cold to more severe disease such as Severe acute respiratory syndrome (SARS) and Middle east respiratory syndrome (MERS). The causative virus for these infections are SARS CoV (first Identified in China, 2002) and MERS CoV (first detected in Saudi Arabia, 2012). Both were declared epidemics and had taken a disastrous roll on human lives. Anew strain (similar to SARS) coined as 2019 Novel corona virus (2019-nCoV) has been identified in late December 2019in Wuhan city of China. The symptoms range from severe fever, cough, shortness of breath, diarrhoea and congestion in nose and throat.There is no specific treatment(s) or vaccine to cure or prevent the infection caused by 2019-nCoV. The entry of virulent strain into target cells of host is believed to be result of interaction of S1 subunit of spike protein of nCoV with ACE2 host receptor. On the basis of above cited hypothesis it is proposed that ACE2 inhibiting drugs or antibodies can be used to promote the denaturation of viral protein which inhibit viral multiplication in the host. Antiviral drugs such as Peginterferon alpha, Ribavirin, Lopinavir and Ritonavir can be used to stop the outbreak of this virus due to protease inhibition by these antiviral agent. Keywords: 2019-nCoV, SARS, MERS, ACE2, RibavirinSummary: POSSIBLE MECHANISM FOR COMBATING 2019-NOVEL CORONA VIRUS INFECTIONReferences: 1) Li, Wenhui; Moore, Michael J.; Vasilieva, Natalya; Sui, Jianhua; Wong, Swee Kee; Berne, Michael A.; Somasundaran, Mohan; Sullivan, John L.; Luzuriaga, Katherine; Greenough, Thomas C.; Choe, Hyeryun (Nov 2003). "Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus". Nature. 426 (6965): 450–454. doi:10.1038/nature02145. ISSN 0028-0836. PMID 14647384 https://www.nature.com/articles/nature02145

2) Antibody Responses Against SARS Coronavirus Are Correlated With Disease Outcome of Infected Individuals https://www.ncbi.nlm.nih.gov/pubmed/16299724

3) The development of vaccines against SARS corona virus in mice and SCID-PBL/hu mice

4) Falzarano D1, de Wit E, Martellaro C, Callison J, Munster VJ, Feldmann H. Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin https://www.ncbi.nlm.nih.gov/pubmed/23594967

5) Structure, Function, and Evolution of Coronavirus Spike Protein https:
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