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Print Me An Organ?
Poster Title: Print Me An Organ?
Submitted on 28 May 2019
Author(s): Amanda Tan; Fatin Nur Syamimi Abdul Razak; Kathy Jia Qi Hu; Diew Fung Lau; Muhammad Hafizan Mustari; Nurul Fatihah Mohamad Azmi; Kar Hui Tan; Nithiyah Ramasundram
Affiliations: Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
This poster was presented at University of Malaya
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Poster Information
Abstract: Human 3D organ printing is one of the major innovations developed in the field of biomedical engineering. It is aided by Bioprinting technologies, which enables the production of life and functional vital organs and tissues such as liver, heart, skin and bone tissues. This innovation differs from cloning whereby it produces cells or tissues artificially rather than genetically identical copy of a cell or an organism. Bioprinting is an additive manufacturing process introduced in 1999 which uses biomaterials such as cells, growth factors and scaffolds combined to create tissue-like structure that imitate natural tissues. Initially, bioprinting aimed at tissue regeneration, albeit now this invention can overcome the shortage of organs for transplantation. Based on the technology and platform used for regular 3D printing, 3D bioprinters have the ability to create biologically functional tissues by dispensing layer after layer of bioink and biogel, left to mature with proper environment, will produce a functional tissue copy with normal metabolic activity. In medical field, 3D bioprinting has already been used for the generation and transplantation of several tissues, including multi-layered skin, bone, vascular grafts, tracheal splints, heart tissue and cartilaginous structures. Issues on tissue rejection by recipients can be minimized as the organs are developed using the same cells of the body they will be placed. In addition, this technique able to repair external organs. Nonetheless, there are certain ethical concerns such as safety, availability to different classes of people and human enforcement that will need to be addressed before this novel technology becomes fully operational and effective. With the progression of bioprinting technology such as handheld 3D printer, and robotic bioprinter, 3D bioprinting will have greater impacts on patient treatment through evolving drug therapies and engineered organ replacements in the futureSummary: 3D bioprinting is a technique that has quickly gained popularity for its ability to create highly aligned tissues. It is a pioneering technology that enables fabrication of biomimetic, multiscale, multi-cellular tissues with highly complex tissue microenvironmentReferences: Murphy, S. V., & Atala, A. (2014). 3D bioprinting of tissues and organs. Nature biotechnology, 32(8), 773. Cui, H., Nowicki, M., Fisher, J. P., & Zhang, L. G. (2017). 3D bioprinting for organ regeneration. Advanced healthcare materials, 6(1), 1601118. Ong, C. S., Yesantharao, P., Huang, C. Y., Mattson, G., Boktor, J., Fukunishi, T., ... & Hibino, N. (2018). 3D bioprinting using stem cells. Pediatric research, 83(1-2), 223. Zopf, D. A., Hollister, S. J., Nelson, M. E., Ohye, R. G., & Green, G. E. (2013). Bioresorbable airway splint created with a three-dimensional printer. New England Journal of Medicine, 368(21), 2043-2045. Baharuddin, A. S., Harun, M. A. W., Ruskam, A., & Yacob, A. R. (2015). THREE-DIMENSIONAL (3D).Report abuse »
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