Abstract: Animal venoms and toxins are a rich source of novel biologics with several making the progression from tool to therapeutic such as FDA approved Integrilintm (Eptifibatide) (Millennium pharmaceuticals)1 derived from Rattlesnake venom for unstable angina. Several other animal toxins are in various stages of research for such applications as antimicrobials, analgesics, thrombosis and even cancer; contortrostatin (copper head, agkistrodon contortrix, venom) reduces metastasies from breast carcinomas 2. Venoms are complex mixtures of peptides, enzymes and smaller biomolecules amongst others, thus representing a vast library of tools. Traditional screening methodologies required single compounds in single wells but with the advent of compressed screening plates, much higher density screens can be run with fewer reagents and in shorter time frames. The Venom Discovery ArrayTM (VDATM) is a naturally compressed hit-to-tool screening plate produced by Venomtech Limited that makes use of natures compressed libraries (venoms) and phylogenetic diversity allowing for maximum discovery potential. These VDA’s can be targeted to specific disease areas with many related species or maximum diversity with up to 96 species from a wide group of animals including snakes, spiders, scorpions and insects.Summary: Animal venoms and toxins are a rich source of novel biologics with several making the progression from tool to therapeutic such as FDA approved Integrilintm (Eptifibatide) (Millennium pharmaceuticals)1 derived from Rattlesnake venom for unstable angina.References: (1) Philips and Scarborough, (1997), The American Journal of Cardiology 80(4): 11-20. (2) Mohit Trikha, Yves A. De Clerck, and Francis S. Markland, (1994) Cancer research. 54:4993-4998.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Genetic Engineering in Male Sterility for Hybrid Variety Development
Abir Hasan Joy
BAT Molecular Imaging with SPECT-CT, PET-CT, PET-MRI and Fluorescence-PET: A Systematic Review of the Literature Data
Tarik Z Belhocine, MD., Ph.D *, Albert A Driedger, MD., Ph.D **, Jean-Luc Urbain, MD., Ph.D ***
Multiplex miRNA Profiling for Biomarker Discovery and Verification Studies Using the FirePlex® Platform
M. Tackett, B. Heinrich, I. Diwan, G. Tejada, C. Rafferty, E. Atabakhsh, and D. Pregibon
Platinum™ SuperFi™ DNA Polymerase for the highest success in PCR
Rasa Sukackaitė, Martyna Simutytė, Skaistė Valinskytė, Laurynas Vanagas, Karolis Matjošaitis, Renata Rimšelienė, Remigijus Skirgaila.
DNA-free Platinum Taq DNA polymerase for reliable microbiome studies
Kęstutis Bargaila, Vytautas Budrys, Andrius Krasauskas, Dovilė Lisauskienė, Milda Romeikaitė, Sonata Jurėnaitė-Urbanavičienė,Ramunė Leipuvienė and Juozas Šiurkus