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Proteomic profiling of IDH mutant gliomas enables prediction of chromosomal copy number variations
Poster Title: Proteomic profiling of IDH mutant gliomas enables prediction of chromosomal copy number variations
Submitted on 05 Oct 2021
Author(s): Marius Felix 1 2 Dennis Friedel 1 2 Ashok Kumar Jayavelu 4 Uwe Warnken 3 Damian Stichel 1 2 Christel Herold Mende 5 Laura Heikaus 6 Andreas von Deimling 1 2 and David E Reuss 1 2
Affiliations: 1 Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany 2 Clinical Cooperation Unit Neuropathology, German Cancer Research Center ( German Consortium for Translational Cancer Research ( Heidelberg, Germany 4 Max Planck Institute of Biochemistry, Martinsried Germany 5 Clinical Cooperation Unit Neurooncology German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany 5 Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany 6 Bruker Daltonik GmbH, Bremen, Germany
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Abstract: Recurrent chromosomal copy number variations (are hallmarks of different types of brain tumors. Status determination is an integral part of WHO classification. There is need for a better understanding of the consequences of gains or deletions involving whole chromosomal arms. A prominent example are IDH mutant gliomas which are separated in two distinct types based on the deletion of chromosomal arms 1 p and 19 q Oligodendrogliomas IDH mutant are 1 p/ 19 q co deleted while astrocytomas IDH mutant are not Therefore, determination of 1 p/ 19 q is important for prognosis and therapy.Summary: •dda PASEF based analysis FFPE tissue highly correlates with FF tissue allowing in depth differential proteomic profiling enabling the discovery of potential new biomarkers
•CPRP is a promising tool for the differentiation of tumors based on chromosomal copy number variation
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