Posters
« Back
Quantitative Cell-Based Bioassays for Immunotherapy Programs Targeting Immune Checkpoint Co-Stimulatory Receptors
EP25818
Poster Title: Quantitative Cell-Based Bioassays for Immunotherapy Programs Targeting Immune Checkpoint Co-Stimulatory Receptors
Submitted on 25 May 2017
Author(s): Jun Wang, Michael Beck, Jamison Grailer, Jim Hartnett, Frank Fan, Mei Cong and Zhi-jie Jey Cheng
Affiliations: Promega Corporation, 2800 Woods Hollow Rd, Madison, WI 53711
Poster Views: 1,101
View poster »


Poster Information
Abstract: Immunotherapy aims to boost a patient’s own immune system to fight disease. Activation of T cells via direct stimulation of the T cell receptor or by modulating immune checkpoint pathways are two strategies being employed individually and in combination. Immune checkpoint targets include co-inhibitory (e.g. PD-1, CTLA-4, TIGIT, LAG-3) and co-stimulatory (e.g. GITR, 4-1BB, OX40, CD40) receptors. Summary: Cell-based reporter bioassays overcome the limitations of primary cell-based assays for functional characterization of antibody and other biologics drugs targeting individual or combination immune checkpoint receptors. Here we show a portfolio of immune checkpoint bioassays that can be used for antibody screening, characterization, potency and stability studies. Report abuse »
Questions
Ask the author a question about this poster.
Ask a Question »

Creative Commons

Related Posters


Dissecting the genomic profile of persistently infecting oncolytic Newcastle disease virus (NDVpi) from cancer RNA-Seq data
Ahmad U1, Chan SC2, Chau DM1, Chia SL5, Abdullah S1,3, Yusoff K5 & Veerakumarasivam A1,4*

Chipcytometry: Long-term Sample Storage and Re-Interrogation in Clinical Trial Support
Jon Waterman-Smith, Anja Mirenska

Depressive mood disorders in relation to T cell abnormalities in a cohort of common variable immune deficiency patients
Olivia Manusama, Hemmo Drexhage, Martin van Hagen, Maksym Ahiyevets, Tom Birkenhäger, Virgil Dalm

Can HIV/AIDS transmit by food?
Shahad sarmad and muhand khalid under the supervision of Dr reem Abu Assi

FINGERPRINT 1H- NMR BASED ON THE CHEMICAL PROFILING OF COLOMBIAN RED PROPOLIS
Guillermo Salamanca Grosso; Monica Patricia Osorio Tangarife; David Garcia Mendez; Julien Wist