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Rapid Separation and Characterization of Chiral Small Molecule Drugs with timsTOF
EP38453
Poster Title: Rapid Separation and Characterization of Chiral Small Molecule Drugs with timsTOF
Submitted on 09 Mar 2022
Author(s): Liling Fang, Xuejun Peng
Affiliations: 1Bruker Scientific LLC, San Jose, CA
Poster Views: 132
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Poster Information
Abstract: It is of crucial importance to rapidly analyze chiral molecules throughout drug discovery and development process to ensure synthesis quality and drug safety1. Chiral HPLC using a chiral stationary phase is a popular method to analyze chiral molecules, however, it is time consuming and costive to select proper chiral column and optimize conditions. Ion-mobility spectrometry –mass spectrometry (IMS-MS), an analytical chemistry method that separates gas phase ions based on their interaction with a collision gas and their mass, has been an important technology to reveal structural diversity of isomers and used for rapid analysis of chiral molecules by a variety of means, involving a reaction with a chiral selector to form diastereomers or complexes2. High resolving power of IMS MS could make it possible to separate enantiomers of small drug and drug-like molecules without any chiral selector3, therefore, has been a focal point for MS vendors and researchers. In this study, the separation power of the trapped ion mobility spectrometry (TIMS) is explored for the rapid separation of racemic drugs Thalidomide, Oxazepam, and Verapamil solely based on the differences of collisional cross section (CCS) of enantiomers.Summary: In this study, the separation power of the trapped ion mobility spectrometry (TIMS) is explored for the rapid separation of racemic drugs Thalidomide, Oxazepam, and Verapamil solely based on the differences of collisional cross section (CCS) of enantiomers.References: (1) Nguyen et al.; International Journal of Biomedical Science, 2006 : 85-100.
(2) Zhang, et al.; Comprehensive Analytical Chemistry, 2019, 83: 51-81.
(3) Philips et al.; Chapter in Methods in molecular biology, Jan 2019, vol. 1939, 161-178.
(4) Blaschke et al.;Arzneim.-Forsch, 1979, 29: 1640-1642.
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