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Response to ragweed allergen provocation in the Red Maple Trials Allergen Challenge TheatreTM
EP22752
Poster Title: Response to ragweed allergen provocation in the Red Maple Trials Allergen Challenge TheatreTM
Submitted on 02 Mar 2015
Author(s): Suzanne Kelly, PHD;Jacob Karsh, MDCM, FRCPC; Jimmy Yang, MBA; William H. Yang, MD, FRCPC, FAAAAI
Affiliations:
This poster was presented at AAAAI 2015 Houston Texas
Poster Views: 1,517
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Poster Information
Abstract: Rationale: Allergen challenge chambers expose allergen-sensitive subjects to a predetermined concentration of allergen in a closed, controlled environment and provide a mechanism to induce clinical symptoms and measure the effect of medication.
Methods: We evaluated the response of ragweed-allergic subjects to two ragweed challenges in the Red Maple Trials Allergen Challenge Theatre. A provincial Ethics Board approved the study. After signing informed consent, patients with a history of ragweed allergy, not on allergy medications and with a positive skin prick test to ragweed antigen (> 3 mm) were exposed to ragweed pollen in a 3-hour priming session. Total nasal (TNSS), ocular and respiratory symptom scores (TRSS) were recorded at baseline and every 30 minutes during the challenge. Those with a TNSS > were then selected for 2 further 4-hour challenges.
Results: 48/76 subjects evaluated underwent the priming challenge. Thirty-three subjects achieving a peak TNSS ≥5 were selected for two subsequent 4-hour challenges. Baseline TNSS (mean± SD) was 1.70 ±1.34 and 2.53±1.76 in challenges 1 and 2, respectively. Baseline TRSS values were 2.00± 1.66 and 3.60±2.69 respectively. Symptom scores reached a plateau by 120 minutes and remained steady for the remainder of the 240-minute exposure period. Plateau TNSS was 6.28±0.20 for Challenge 1and 6.19±0.24 for Challenge 2. Similarly, TRSS values were 9.10±0.20 and 9.11± 0.33, respectively.
Conclusions: The Red Maple Trials allergen exposure theatre demonstrated the capacity to induce symptoms of appropriate intensity upon allergen challenge. Our chamber with a seating capacity of 100 places has the ability to evaluate large test groups at a time.
Summary: Response to ragweed allergen provocation in the Red Maple Trials Allergen Challenge TheatreReferences: Kelly S, Yang WH, Yang J, Perrins R, Gerwing D, Karsh J. Technical evaluation of an allergen challenge theatre. Allergy 69 (Suppl 99):458, 2014.
Karsh J, Kelly S, Yang J, Perrins R, Yang WH. Clinical evaluation of an Allergen Challenge TheatreTM. Allergy, Asthma and Clinical Immunology 10 (Suppl 2):A21, 2014.
Kelly S, Yang J, Perrins R, Karsh J, Yang WH.  Technical evaluation of an Allergen Challenge TheatreTM.  Allergy, Asthma and Clinical Immunology 10 (Suppl 2):A22, 2014
Day, J. The Environmental Exposure Unit: a system to test anti-allergic treatment. Clinical and Experimental Allergy Reviews. 2003; 3: 82-86.
Jacobs, R.L., Harper, N., He, W., Andrews, C.P., Rather, C.G., Ramirez, D.A. and Ahuja, S.K. Responses to ragweed pollen in a pollen challenge chamber versus seasonal exposure identify allergic rhinoconjunctivitis endotypes. Journal of Allergy and Clinical Immunology. 2012; 130: 122-127.
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