Abstract: Leptin(LEP) is a protein product encoded by obese gene which was located on chromosome number 7. It is circulating hormone produced by the adipose tissue primarily. It helps to regulate body weight by sending signals to arcuate nucleus present in hypothalamus of the brain. Leptin also known as satiety or starvation hormone. Mutations of gene encoding leptin becomes morbidly obese, infertile, hyperphagic, hypothermic and diabetic. It serves as an adiposity signal to inform the brain the adipose tissues mass in a negative feedback loop regulating food intake. Leptin also plays an important role in angiogenesis, immune modulation, fertility, cognition and bone formation. By enhancing or inhibiting leptin’s activities in- vivo may have potential benefits.Summary: Many studies showed that the significant role of leptin in many physiological function. But, only few drugs are available in the market. Leptins are better choice for people having multi morbidities. Leptin may be a better choice for multiple comorbidities instead of multiple drug therapy for single disease. There is a need for development of biotechnology derived leptin products like insulin. References: https://www.urhormones.info/harmone/leptin/
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