Abstract: DNA methylation predominantly occurs in CpGs but is also found in non-CpG contexts. DNA methylation is heritable and has been associated with multiple cellular processes, including transcriptional repression, transposon inactivation, X chromosome inactivation, embryonic development, genomic imprinting, and the alteration of chromatin structure.Summary: DNA methylation, one of the most studied epigenetic modifications, refers to the addition of a methyl group to the fifth carbon of cytosine (C) catalyzed by DNA methyltransferases (Dnmts), forming 5-methylcytosine (5mC). References: https://www.cd-genomics.com/wp-content/themes/v1/pdf/main/Sequencing-based-methods-for-profiling-DNA-methylation.pdf
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