Abstract: Single domain antibody, also known as domain antibody, such as VHH, VNAR or sdAb, is a kind of antibody fragments consisting of a single monomeric variable antibody domain and lacking the light chain and CH1 domain of the heavy chain in conventional Fab region. The first single domain antibody was engineered from the VHH domain of heavy-chain antibody identified in camelids (e.g. dromedaries, camels, llamas, and alpacas). And the VNAR domain of cartilaginous fishes (e.g. shark) heavy-chain antibody (known as IgNAR, immunoglobulin new antigen receptor) is another qualified source for sdAb development.Summary: In terms of these advantages compared with the conventional antibody, sdAb presents great applications in many aspects including biological diagnosis, medical imaging, and immunodetection. Equipped with advanced platforms and extensive experience, Creative Biolabs is a well-recognized leader in the field of sdAb discovery and engineering.
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