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TFAP2B is Associated with WNT/ß-catenin Pathway in Luminal Breast Cancer
EP22562
Poster Title: TFAP2B is Associated with WNT/ß-catenin Pathway in Luminal Breast Cancer
Submitted on 15 Dec 2014
Author(s): Benjamin Otto1,2, Kristin Klätschke2, Thomas Streichert3, Christoph Wagener2, Genrich Tolstonog4
Affiliations: 1. Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Germany 2. Department of Clinical Chemistry, University Medical Center Hamburg-Eppendorf, Germany 3. Department of Clinical Chemistry, University Medical Center Cologne, Germany 4. Department of Otolaryngology – Head and Neck Surgery, CHUV, University of Lausanne, 1011 Lausanne, Switzerland
This poster was presented at Genomics Research Europe 2013
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Abstract: Identification and prediction of breast cancer subtypes is a wide and highly investigated research field. Many research groups have identified and reported subtype specific signatures. Common to many of these signatures is the supervised approach where specific phenotype associated features are provided as input. We identified TFAP2B in an unsupervised approach and show that the expression correlates with two distinct subgroups of luminal breast cancer which are not identical with Luminal A/B subgrouping. Though several publications describe the association of AP-2α and AP-2γ with breast cancer, AP-2β ist still hardly investigated in the context of breast cancer. Here we investigated the TFAP2B correlations and show that TFAP2B is associated with the WNT/ß-catenin signaling pathway.Summary: Here we aimed to investigate which molecular mechanisms are associated with TFAP2B expression in luminal breast cancer.Report abuse »
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