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The P450-Glo™ CYP2B6 Assay: a Rapid and Selective Assay for Measuring CYP2B6 Induction and Inhibition
EP23517
Poster Title: The P450-Glo™ CYP2B6 Assay: a Rapid and Selective Assay for Measuring CYP2B6 Induction and Inhibition
Submitted on 09 Oct 2015
Author(s): Dongping Ma, Hui Wang, Poncho Meisenheimer, James J. Cali
Affiliations: Promega Corporation
Poster Views: 1,169
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Poster Information
Abstract: We have developed a luminogenic CYP2B6 assay for biochemical CYP2B6 inhibition and for cell-based CYP2B6 induction studies. Here we present the CYP2B6 luminogenic assay characterization and demonstrate its utility for measuring time dependent CYP2B6 inhibition, and for measuring CYP2B6 induction in cultured primary human hepatocytes with normalization to viable cell count.Summary: We have developed a luminogenic CYP2B6 assay for biochemical CYP2B6 inhibition and for cell-based CYP2B6 induction studies. Here we present the CYP2B6 luminogenic assay characterization and demonstrate its utility for measuring time dependent CYP2B6 inhibition, and for measuring CYP2B6 induction in cultured primary human hepatocytes with normalization to viable cell count.References: Dongping Ma1, Hui Wang 2, Poncho Meisenheimer 2, James J. Cali1
1R & D, Promega Corporation, Madison, WI 53711; 2R & D, Promega Biosciences, San Luis Obispo, CA 93401
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